Name: NEO-811
Brand: TargetMol
SKU: T217535
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

¥ 2,750

10-14周

5 mg

¥ 6,320

10-14周

25 mg

¥ 14,500

10-14周

100 mg

¥ 32,000

10-14周

生物活性

产品描述	NEO-811 is a potent, selective, and cereblon (CRBN)-dependent E3 ubiquitin ligase-mediated proteolytic inhibitor that targets ARNT (HIF-1β). NEO-811 blocks the ccRCC signaling pathway by degrading ARNT, thereby inhibiting the survival and proliferation of tumor cells. NEO-811 is suitable for use in studies of clear cell renal cell carcinoma (ccRCC).
体内活性	在透明细胞肾细胞癌（ccRCC）异种移植模型（含 HIF-2α G323E 耐药突变）及患者来源异种移植（PDX）模型中，体内 NEO-811 单药可诱导 ccRCC 肿瘤消退，对 HIF-2α 拮抗剂耐药的 G323E 突变模型仍有效；PDX 模型中抗肿瘤活性优于临床 HIF-2 拮抗剂与 VEGFR 酪氨酸激酶抑制剂。[1]

化学信息

分子量	543.59
分子式	C₃₀H₃₀FN₅O₄
CAS No.	3084635-77-5
Smiles	O[C@]1(C(C)(C)CN(CC2=CC=C(C=C2)C=3N=CON3)CC1)C4=C(F)C5=C(C=C4)N=CC(=C5)C6C(=O)NC(=O)CC6

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

NEO-811