Name: CAT-2200
Brand: TargetMol
SKU: T9901A-1447
Rating: 4.5 (1 reviews)

生物活性

产品描述	CAT-2200 is a human monoclonal antibody (IgG1/lambda) targeting Interleukin-17A (IL-17A/CTLA-8). IL-17A is a critical pro-inflammatory cytokine produced by Th17 cells, playing a central role in the pathology of autoimmune diseases such as psoriasis, rheumatoid arthritis, and multiple sclerosis. CAT-2200 specifically binds to the IL-17A homodimer, blocking its interaction with cell surface receptors (IL-17RA/IL-17RC), thereby effectively neutralizing the biological activity of IL-17A. Studies demonstrate that CAT-2200 significantly inhibits the IL-17A-induced release of downstream inflammatory mediators (e.g., IL-6, IL-8, and GRO-alpha). This antibody is frequently used as a tool antibody or positive control for researching the IL-17A signaling pathway and its role in inflammatory responses.
靶点活性	IL-8:~8 nM, IL-6:~8 nM
体外活性	CAT-2200 以皮摩尔级亲和力结合人 IL-17A。在原代软骨细胞或成纤维细胞中，它剂量依赖性地抑制 IL-6 和 IL-8 的分泌（IC50 ≈ 8 nM）。结构分析显示其结合 IL-17A 二聚体，通过空间位阻阻碍受体结合 [1]。
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	Q16552
靶点	CTLA-8/IL-17a

储存&溶解度

存储

CAT-2200