Powder: -20°C for 3 years In solvent: -80°C for 2 years
ML228 是一种有效的 HIF 信号通路激活剂，EC50 为 1 μM。ML228 可激活 HIF 以及下游 EGFR。
| 产品描述 | ML228 is a potent the Hypoxia Inducible Factor (HIF) pathway activator with EC50 of 1 μM. ML228 potently activates HIF in vitro as well as its downstream target VEGF. |
| 体外活性 | ML228 represents a novel chemotype available to the research community for the study of HIF activation and its therapeutic potential. Not only is the compound substantially different in structure from known HIF activators, ML228 lacks the acidic functional group almost universally present in PHD inhibitors, which may be important for certain disease applications[1][2]. |
| 体内活性 | ML228 (injection; 1 µg/kg; 7 days) treatments following spinal cord injury (SCI) improves the local hypoxic ischemia environment, reduces SCI secondary injury and promotes the recovery of neurological function[3]. |
| 分子量 | 415.5 |
| 分子式 | C27H21N5 |
| CAS No. | 1357171-62-0 |
Powder: -20°C for 3 years In solvent: -80°C for 2 years
DMSO: 30 mg/mL (72.2 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
参考文献
剂量换算对于不同动物的给药剂量换算，您也可以参考 更多
体内实验配液计算器计算器bottom
您可能有的问题的答案可以在抑制剂处理说明中找到，包括如何准备库存溶液，如何存储产品，以及基于细胞的分析和动物实验需要特别注意的问题。
ML228 1357171-62-0 Chromatin/Epigenetic Angiogenesis HIF Inhibitor inhibitor inhibit
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