Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DDO-7263 是一种 1,2,4-Oxadiazole 衍生物, 通过与 Rpn6 结合上调 Nrf2,从而阻断 26S 蛋白酶体的组装和随后Nrf2 的泛素化降解。DDO-7263 是一种有效的Nrf2激活剂,能够激活 Nrf2-ARE 信号通路并发挥抗炎活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 623 | 现货 | ||
5 mg | ¥ 1,530 | 现货 | ||
10 mg | ¥ 2,820 | 现货 | ||
25 mg | ¥ 4,490 | 现货 | ||
50 mg | ¥ 6,230 | 现货 | ||
100 mg | ¥ 7,890 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,690 | 现货 |
产品描述 | DDO-7263 is a 1,2,4-Oxadiazole derivative that upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 is a potent Nrf2 activator that activates the Nrf2-ARE signaling pathway and exerts anti-inflammatory activity [1]. |
体外活性 | DDO-7263 (20 μM; 2-24 h) can upregulate the protein levels of NQO1 and HO-1. DDO-7263 (2.5, 5, 10, 20, 40, 80 μM; 24 h) can upregulate the survival rate of THP-Ms and PC12 cell after treatment of 400μM H2O2 in a concentration-dependent manner. DDO-7263 has no significant decrease on cell survival rate[1]. |
体内活性 | DDO-7263 (10-100 mg/kg/day; IP; for 10 days) improves the behavioral abnormalities induced by MPTP in mice, significantly attenuates chemically induced dopaminergic neuron loss of tyrosine hydroxylase (TH) in the substantia nigra (SN) and striatum of the mouse brain and inhibits the secretion of inflammatory factors. DDO-7263 (7, 35, 70 mg/kg; IP) has a T1/2 of 3.32 hours and a Cmax of 1.38 mg/mL for rats[1]. |
分子量 | 273.24 |
分子式 | C14H9F2N3O |
CAS No. | 2254004-96-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16.1 mg/mL (58.8 mM), Sonication and heating to 60℃ are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.6598 mL | 18.2989 mL | 36.5979 mL | 91.4947 mL |
5 mM | 0.732 mL | 3.6598 mL | 7.3196 mL | 18.2989 mL | |
10 mM | 0.366 mL | 1.8299 mL | 3.6598 mL | 9.1495 mL | |
20 mM | 0.183 mL | 0.9149 mL | 1.8299 mL | 4.5747 mL | |
50 mM | 0.0732 mL | 0.366 mL | 0.732 mL | 1.8299 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
DDO-7263 2254004-96-9 Immunology/Inflammation Nrf2 Inhibitor inhibitor inhibit