Name: PTX-35
Brand: TargetMol
SKU: T9901A-1027
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

¥ 12,000

待询

5 mg

待询

生物活性

产品描述	PTX-35 is a potential first-in-class agonistic monoclonal antibody targeting Tumor Necrosis Factor Receptor Superfamily Member 25 (TNFRSF25, also known as DR3). By specifically activating the TNFRSF25 signaling pathway, the compound modulates T-cell immune responses, particularly within the tumor microenvironment. In experimental studies, PTX-35 has been demonstrated to reduce the suppressive activity of regulatory T cells (Tregs) and enhance CD4+ effector T-cell responses to tumor antigens, exhibiting significant anti-tumor potential.
体外活性	在免疫学实验中，PTX-35 作为 TNFRSF25 激动剂特异性调节 T 细胞亚群，通过降低 Treg 的抑制功能并促进效应 T 细胞的活化，展现了重塑免疫应答的能力 [1]。
体内活性	在小鼠黑色素瘤模型中，在肿瘤抗原存在的情况下，通过全身给药方式给予 PTX-35，实验结果显示其显著增强了 CD4+ 效应 T 细胞的反应，并成功限制了肿瘤部位调节性 T 细胞的抑制作用 [1]。
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	Q93038
靶点	DR3

储存&溶解度

存储

PTX-35