Name: RNF43 Protein, Mouse, Recombinant (hFc)
Brand: TargetMol
SKU: TMPK-01001
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 μg

¥ 313

6-8日内发货

10 μg

¥ 498

6-8日内发货

20 μg

¥ 793

5日内发货

50 μg

¥ 1,580

5日内发货

100 μg

¥ 2,660

5日内发货

200 μg

¥ 4,790

5日内发货

500 μg

¥ 10,600

5日内发货

生物活性

产品描述	RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation.
生物活性	Immobilized Mouse R spondin 1, His Tag at 2μg/ml (100μl/Well) on the plate. Dose response curve for Mouse RNF43, hFc Tag with the EC50 of 0.40μg/ml determined by ELISA.
研究背景	RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation.
种属	Mouse
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	Q5NCP0
蛋白构建	Gly24-Tyr197
蛋白纯度	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
别名	Rnf43, RING-type E3 ubiquitin transferase RNF43, RING finger protein 43, E3 ubiquitin-protein ligase RNF43
内毒素	< 1 EU/μg by the LAL method.

化学信息

分子量	45.6 kDa (predicted). Due to glycosylation, the protein migrates to 53-60 kDa based on Tris-Bis PAGE result.

储存&溶解度

运输方式	In general, Lyophilized powders are shipping with blue ice.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

RNF43 Protein, Mouse, Recombinant (hFc)

RNF43 Protein, Mouse, Recombinant (hFc)

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