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GITR/TNFRSF18 Protein, Cynomolgus, Recombinant (aa 20-156, His)
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货号 TMPK-01260
别名 TNFRSF18, GITR-D, GITR, CD357, AITR
GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. GITR/TNFRSF18 Protein, Cynomolgus, Recombinant (aa 20-156, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 15.87 kDa and the accession number is XP_005545180.2.
其他形式的 “GITR/TNFRSF18 Protein, Cynomolgus, Recombinant (aa 20-156, His)”:
GITR/TNFRSF18 Protein, Cynomolgus, Recombinant (aa 20-156, His)
一键复制产品信息 还可以SPR兼容缓冲液
货号 TMPK-01260 别名 TNFRSF18, GITR-D, GITR, CD357, AITR
GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. GITR/TNFRSF18 Protein, Cynomolgus, Recombinant (aa 20-156, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 15.87 kDa and the accession number is XP_005545180.2.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5 μg | ¥ 358 | 6-8日内发货 | |
| 10 μg | ¥ 573 | 6-8日内发货 | |
| 20 μg | ¥ 938 | 5日内发货 | |
| 50 μg | ¥ 1,830 | 5日内发货 | |
| 100 μg | ¥ 3,100 | 5日内发货 | |
| 200 μg | ¥ 5,620 | 5日内发货 | |
| 500 μg | ¥ 12,400 | 5日内发货 |
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| 产品描述 | GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. GITR/TNFRSF18 Protein, Cynomolgus, Recombinant (aa 20-156, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 15.87 kDa and the accession number is XP_005545180.2. |
| 生物活性 | 1. Immobilized Cynomolgus GITR, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-GITR Antibody, hFc Tag with the EC50 of 7.6ng/ml determined by ELISA (QC Test).
2. Cynomolgus GITR Ligand, His Tag immobilized on CM5 Chip can bind Cynomolgus GITR, His Tag with an affinity constant of 0.21 μM as determined in SPR assay. |
| 研究背景 | GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. |
| 种属 | Cynomolgus |
| 表达系统 | HEK293 Cells |
| 标签 | C-His |
| 蛋白编号 | XP_005545180.2 |
| 蛋白构建 | Gln20-Pro156 |
| 蛋白纯度 | > 95% as determined by Tris-Bis PAGE |
| 蛋白性状 | Lyophilized powder |
| 缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization. |
| 复溶方法 | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| 别名 | TNFRSF18, GITR-D, GITR, CD357, AITR |
| 内毒素 | < 1 EU/μg by the LAL method. |
| 分子量 | 15.87 kDa (predicted). Due to glycosylation, the protein migrates to 25-30 kDa based on Tris-Bis PAGE result. |
| 运输方式 | In general, Lyophilized powders are shipping with blue ice. |
| 存储 | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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