T 20

Enfuvirtide acetate 是一种抗HIV-1融合的抑制肽，是一种由 36 个氨基酸组成的线性合成肽。 它具有乙酰化的 N 端和羧酰胺 C 端。

Inhibits interaction of APC and Asef (RhoGEF4). Inhibits colorectal cancer cell migration and invasion in vitro.

Tet-20是一种合成导管素衍生的生物活性肽。此化合物作为医疗器械抗感染涂层的测试表明，它固定于植入物表面后，在体内和体外均展现了广泛的抗菌活性，能有效抑制生物膜的形成，且对真核细胞无毒。

MAIT-203为环戊丙氨酸衍生的拟肽，专一抑制APC和Asef (RhoGEF4)的相互作用，不影响APC-Sam68或APC-striatin。该化合物与APC-ARM结合紧密，Ki值为0.015 μM，Kd值为0.036 μM，并有效抑制结直肠癌细胞的迁移与侵袭。

MAIT-203 acetate 是一种衍生自环戊丙氨酸的拟肽，主要抑制腺瘤性息肉病 (APC) 与 Asef (RhoGEF4) 的相互作用，不影响 APC-Sam68 或 APC-striatin 的相互作用。其与 APC-ARM 的结合有 Ki值为 0.015 μM 和 Kd值为 0.036 μM。MAIT-203 acetate 还能够显著抑制结直肠癌细胞的迁移和侵袭。

CT20p 是一种抗癌型多肽，其结构基于BaxC的疏水性末端。CT20p 展现出独特的细胞毒性作用，独立于全长Bax，与线粒体作用并导致融合样聚集及线粒体膜超极化。它能降低α5β1整合素水平，抑制F-肌动蛋白的聚合，从而干扰细胞骨架并阻止细胞附着，适用于乳腺癌研究。

Amyloid-β (25-35) (Aβ (25-35)) is an 11-residue fragment of the Aβ protein that retains the physical and biological characteristics of the full length peptide. It forms fibrils that react to thioflavin T and Congo red and are organized in a cross-β arrangement of β-strands similar to Aβ (1-40) and Aβ (1-42) fibrils. Aggregated Aβ (25-35) decreases the viability of rat adrenal PC12 cells. It also decreases the viability of primary rat cortical neurons at concentrations ranging from 1 nM to 30 μM. In vivo, intracerebral injection of Aβ (25-35) (20 nmol) in rats induces lesions of neuronal and tissue loss. Aggregated Aβ (25-35) administered intracerebroventricularly to rats induces learning and memory impairments in the Y-maze, novel object recognition, and contextual fear conditioning tests.

Siamycin I is a tricyclic peptide originally isolated from Streptomyces and has antiviral and antibacterial activities. It is active against laboratory strains and clinical isolates of HIV-1 (ED50s = 0.05-0.45 and 0.89-5.7 μM, respectively), as well as the CBL-20 strain of HIV-2 (ED50 = 0.45 μM), in vitro. Siamycin I inhibits HIV-induced fusion of C8166 T cells with HIV-1-infected CEM-SS cells with an ED50 value of 0.08 μM. It is also active against B. subtilis, M. luteus, and S. aureus (MICs = 1.6-6.3 μg/ml). Siamycin I inhibits autophosphorylation of the E. faecalis quorum sensing kinase FsrC induced by gelatinase biosynthesis-activating pheromone (GBAP).

TPP-1是一种针对程序化细胞死亡蛋白1(PD-1)及其配体PD-1配体(PD-L1)之间蛋白-蛋白相互作用的肽抑制剂。它在无细胞实验中结合到PD-L1(Kd = 94.67 nM)。TPP-1 (20 µM)能逆转PD-L1在抗CD3激活的人类CD4+ T细胞中所引起的干扰素γ(IFN-γ)水平的下降。在使用HL-60白血病细胞与抗CD3激活的人类CD4+ T细胞共培养并在植入前预处理时，以4 mg/kg的剂量给药，可减少小鼠异种移植模型中的肿瘤体积。

HPV16-E711-20 epitope is a well-known HLA-A*0201-restricted human cytotoxic T lymphocyte (CTL) epitope of the HPV16 E7 protein, demonstrating high-affinity binding to HLA-A2 in vitro.