规格

价格

库存

数量

1 mg

¥ 1,090

待询

生物活性

产品描述	METTL16-IN-1 is a potent METTL16 inhibitor with an IC50 value of 1.7 μM and a Kd value of 1.35 μM. METTL16-IN-1 effectively suppresses the binding of U6 snRNA deletion constructs to the METTL16 methyltransferase domain (MTD), with an IC50 value of 2.5 μM. METTL16-IN-1 additionally exhibits antitumor activity. METTL16-IN-1 is therefore applicable to investigations involving RNA methylation, epitranscriptomic regulation, spliceosomal biology, and tumor-associated METTL16 signaling pathways.
体外活性	METTL16-IN-1 (Compound 45) (12.5-50 μM；24 小时) 在MDA-MB-231和A549细胞中促进MAT2A的剪接，增加总m6A mRNA水平[1]。
别名	METTL16 抑制剂 1

化学信息

分子量	522.35
分子式	C₁₉H₁₂BrN₃O₆S₂
Smiles	CN(C1=C(/C2=C3C(N=C(NS(C4=CC=C(C(O)=O)C=C4)(=O)=O)S\3)=O)C=C(Br)C=C1)C2=O

储存&溶解度

存储

Keep away from moisture,Keep away from direct sunlight, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 80 mg/mL (153.15 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9144 mL	9.5721 mL	19.1443 mL	95.7213 mL
5 mM	0.3829 mL	1.9144 mL	3.8289 mL	19.1443 mL
10 mM	0.1914 mL	0.9572 mL	1.9144 mL	9.5721 mL
20 mM	0.0957 mL	0.4786 mL	0.9572 mL	4.7861 mL
50 mM	0.0383 mL	0.1914 mL	0.3829 mL	1.9144 mL
100 mM	0.0191 mL	0.0957 mL	0.1914 mL	0.9572 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

METTL16-IN-1

METTL16-IN-1

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

METTL16-IN-1

METTL16-IN-1

METTL16-IN-1 相关产品

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换