Name: RP-1664
Brand: TargetMol
SKU: T206047
Rating: 4.5 (1 reviews)

产品介绍

生物活性

产品描述	RP-1664 is a selective and orally active PLK4 inhibitor with an IC50 of 3 nM. This compound demonstrates exceptional selectivity over related kinases, disrupts centriole biogenesis in cancer cells leading to PLK4 and p21 protein accumulation, shows enhanced sensitivity in TRIM37-high-expressing cells, and exhibits antitumor activity in breast cancer and neuroblastoma research.
体外活性	方法：RP-1664（1-1000 nM，48-72小时）处理RPE1-hTERT Cas9 TP53 基因敲除细胞和 RPE1-hTERT Cas9 TP53 野生型细胞，Western Blot 分析目标蛋白的表达情况。结果：RPE1-hTERT Cas9 TP53 基因敲除细胞中 PLK4 总蛋白水平升高，RPE1-hTERT Cas9 TP53 野生型细胞中 p21 蛋白水平呈剂量依赖性升高。[1]
别名	RP1664

化学信息

分子量	514.55
分子式	C₂₃H₂₄F₂N₈O₂S
CAS No.	2980682-00-4
Smiles	O=S(=O)(C1=CC(F)=C(C(F)=C1)N(C=2N=C(NC3=NNC(=C3)C)C(=C(N2)C=4N=CN(C4)C)C5CC5)C)C
密度	no data available

储存&溶解度

存储

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 80 mg/mL (155.48 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9434 mL	9.7172 mL	19.4345 mL	97.1723 mL
5 mM	0.3887 mL	1.9434 mL	3.8869 mL	19.4345 mL
10 mM	0.1943 mL	0.9717 mL	1.9434 mL	9.7172 mL
20 mM	0.0972 mL	0.4859 mL	0.9717 mL	4.8586 mL
50 mM	0.0389 mL	0.1943 mL	0.3887 mL	1.9434 mL
100 mM	0.0194 mL	0.0972 mL	0.1943 mL	0.9717 mL

体内实验配液计算器