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CD45 Protein, Mouse, Recombinant (aa 453-1152)

产品编号 TMPY-03468

别名: loc, Lyt-4, protein tyrosine phosphatase, receptor type, C, T200, L-CA, B220, Ly-5, CD45R, Cd45

CD45 Protein, Mouse, Recombinant (aa 453-1152) is expressed in Baculovirus insect cells. The predicted molecular weight is 81 kDa and the accession number is AAA39458.1.

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CD45 Protein, Mouse, Recombinant (aa 453-1152)

规格	价格/CNY		货期	数量
100 μg	￥ 5,750		5日内发货

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参考文献

生物活性	1. The specific activity was determined to be 9168 nmol/min/mg using p-nitrophenyl phosphate as substrate. 2. Measured by its binding ability in a functional ELISA. Immobilized mouse PTPRC (453-1152) at 10 μg/ml (100 μl/well) can bind biotinylated human Galectin-1 with a linear range of 0.31-2.5 μg/ml.
产品描述	CD45 Protein, Mouse, Recombinant (aa 453-1152) is expressed in Baculovirus insect cells. The predicted molecular weight is 81 kDa and the accession number is AAA39458.1.

种属	Mouse
表达系统	Baculovirus Insect Cells
标签	Tag Free
蛋白编号	AAA39458.1
别名	loc, Lyt-4, protein tyrosine phosphatase, receptor type, C, T200, L-CA, B220, Ly-5, CD45R, Cd45
蛋白构建	The Mouse PTPRC (AAA39458.1) (Arg453-Ser1152) was fused with five amino acids (DDDDK) at the C-terminus was expressed and purified.
蛋白纯度	> 85 % as determined by SDS-PAGE
分子量	81 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Supplied as sterile 20 mM Tris, 500 mM NaCl, 10% glycerol, 3 mM DTT, pH 7.4.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store the product under sterile conditions at -20℃ to -80℃. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.
研究背景	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Protein tyrosine phosphatase, receptor type C (CD45), also known as PTPRC is a member of the protein tyrosine phosphatase (PTP) family which is known for its function to serve as signaling molecules and to regulate a variety of cellular processes such as cell proliferation, differentiation, mitotic cycle and oncogenic transformation. CD45 is found expression specifically in hemotopietic cells. CD45 consists of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. It serves as an essential regulator of T-cell and B-cell antigen receptor signaling through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling and it also can suppress JAK kinases.

参考文献

1. Zola H,et al.(2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5. 2. Ho IC,et al.(2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35. 3. Matesanz-Isabel J,et al.(2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12. 4. Irie-Sasaki J,et al.(2001) CD45 is a JAK phosphatase and negatively regulates cytokine receptor signaling. Nature. 409: 349-54.

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Keywords

CD45 Protein, Mouse, Recombinant (aa 453-1152) loc Lyt-4 protein tyrosine phosphatase, receptor type, C T200 T 200 B 220 B-220 L-CA B220 T-200 Ly-5 CD45R Cd45 recombinant recombinant-proteins proteins protein

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