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Anti-CD45 Antibody (6K117)
还可以产品编号 TMAY-00449
Anti-CD45 Antibody (6K117) 是一种 Mouse 抗体，靶向 CD45。Anti-CD45 Antibody (6K117) 可用于 WB,IHC-P。
Anti-CD45 Antibody (6K117)
Anti-CD45 Antibody (6K117)
还可以产品编号 TMAY-00449
Anti-CD45 Antibody (6K117) 是一种 Mouse 抗体，靶向 CD45。Anti-CD45 Antibody (6K117) 可用于 WB,IHC-P。
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| 产品描述 | Anti-CD45 Antibody (6K117) is a Mouse antibody targeting CD45. Anti-CD45 Antibody (6K117) can be used in WB,IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 6K117 |
| 交叉反应 | Human |
| 验证活性 | 1. Anti-PTPRC mouse monoclonal antibody at 1:500 dilution. -Lane A: Jurkat Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG (H+L)/HRP at 1/10000 dilution. -Developed using the ECL technique. -Performed under reducing conditions. -Predicted band size:143 kDa. 2. Immunochemical staining of mouse PTPRC in human spleen with mouse monoclonal antibody at 1:60 dilution, formalin-fixed paraffin embedded sections. 3. Immunochemical staining of mouse PTPRC in human lymphoma with mouse monoclonal antibody at 1:60 dilution, formalin-fixed paraffin embedded sections. |
| 应用 | WB,IHC-P |
| 推荐剂量 | WB: 1:500-1:2000; IHC-P: 1:30-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the C-terminus of the Human CD45/Ptprc. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Protein tyrosine phosphatase, receptor type C (CD45), also known as PTPRC is a member of the protein tyrosine phosphatase (PTP) family which is known for its function to serve as signaling molecules and to regulate a variety of cellular processes such as cell proliferation, differentiation, mitotic cycle and oncogenic transformation. CD45 is found expression specifically in hemotopietic cells. CD45 consists of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. It serves as an essential regulator of T-cell and B-cell antigen receptor signaling through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling and it also can suppress JAK kinases. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide corresponding to the C-terminus of the Human CD45/Ptprc |
| 抗原种属 | Human |
| 研究领域 | Phosphatases and Regulators |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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