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CD45 Protein, Human, Recombinant (aa 26-577, His)

CD45 Protein, Human, Recombinant (aa 26-577, His)

产品编号 TMPY-05748
别名: L-CA, T200, LCA, B220, protein tyrosine phosphatase, receptor type, C, CD45R, GP180, LY5, CD45

CD45 Protein, Human, Recombinant (aa 26-577, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62.2 kDa and the accession number is P08575-3.

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CD45 Protein, Human, Recombinant (aa 26-577, His)
规格 价格/CNY 货期 数量
50 μg ¥ 2,320 现货
100 μg ¥ 4,120 5日内发货
200 μg ¥ 7,270 5日内发货
500 μg ¥ 15,380 5日内发货
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产品目录号及名称: CD45 Protein, Human, Recombinant (aa 26-577, His) (TMPY-05748)
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生物活性 Testing in progress
产品描述 CD45 Protein, Human, Recombinant (aa 26-577, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62.2 kDa and the accession number is P08575-3.
种属 Human
表达系统 HEK293 Cells
标签 C-His
蛋白编号 P08575-3
别名 L-CA, T200, LCA, B220, protein tyrosine phosphatase, receptor type, C, CD45R, GP180, LY5, CD45
蛋白构建 The Human CD45 (NP_002829.3) (Gln26-Lys577) was expressed with a polyhistidine tag at the C-terminus.
蛋白纯度 > 95% as determined by SDS-PAGE.

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分子量 62.2 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Protein tyrosine phosphatase, receptor type C (CD45), also known as PTPRC is a member of the protein tyrosine phosphatase (PTP) family which is known for its function to serve as signaling molecules and to regulate a variety of cellular processes such as cell proliferation, differentiation, mitotic cycle and oncogenic transformation. CD45 is found expression specifically in hemotopietic cells. CD45 consists of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. It serves as an essential regulator of T-cell and B-cell antigen receptor signaling through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling and it also can suppress JAK kinases.

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Keywords

CD45 Protein, Human, Recombinant (aa 26-577, His) T-200 LY-5 GP-180 L-CA T200 LY 5 LCA B220 B-220 T 200 CD 45 protein tyrosine phosphatase, receptor type, C CD45R GP180 CD-45 LY5 B 220 CD45 GP 180 recombinant recombinant-proteins proteins protein

 

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