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4-Nitrobenzoic acid

Name: 4-Nitrobenzoic acid
Brand: TargetMol
SKU: T20882
Price: 148 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 98.85

货号 T20882Cas号 62-23-7

别名 Nitrodracylic acid, Kyselina p-nitrobenzoova, 4-硝基苯甲酸, 4Nitrobenzoic acid, 4 Nitrobenzoic acid

4-Nitrobenzoic acid (4Nitrobenzoic acid) 是一种药物中间体，常在叶酸、DABA、PABA 和染料的生产中出现。

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4-Nitrobenzoic acid

一键复制产品信息

很棒

纯度: 98.85

货号 T20882 别名 Nitrodracylic acid, Kyselina p-nitrobenzoova, 4-硝基苯甲酸, 4Nitrobenzoic acid, 4 Nitrobenzoic acidCas号 62-23-7

4-Nitrobenzoic acid (4Nitrobenzoic acid) 是一种药物中间体，常在叶酸、DABA、PABA 和染料的生产中出现。

规格	价格	库存
25 mg	¥ 148	现货
50 mg	¥ 208	现货
100 mg	¥ 292	现货
500 mg	¥ 708	现货
1 g	¥ 1,050	现货
2 g	¥ 1,560	现货
5 g	¥ 2,590	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98.85

颜色: 白色

性状: Solid

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资源下载:

COA HPLC HNMR 产品操作手册

产品介绍

4-Nitrobenzoic acid AI Summary

4-Nitrobenzoic acid is a multifaceted bioactive molecule exhibiting a range of biochemical and pharmacological activities. It has a Hammett constant of 0.78, indicating its electronic effect in chemical reactions. With a partition coefficient (LogD) of 1.84, it is moderately lipophilic, and its log LD50 value of -1.52 suggests a notable toxicological profile. The inhibitory potency of the compound is reflected by a pI50 value of 501187.23 nM in a specific assay, and it achieves notable concentrations in rat kidney and liver, with Log M values of 1.02 and 0.79, respectively. Additionally, it binds to beta cyclodextrin with a log Ks value of 2.34 and inhibits human kidney thiopurine methyltransferase (TPMT) with an IC50 of 501187.23 nM. 4-Nitrobenzoic acid demonstrates significant multifunctional bioactivities, including inhibition of Tyrosyl-DNA Phosphodiesterase (TDP1), blocking Anthrax Lethal Toxin Internalization, antagonizing thyroid hormone receptor beta signaling and peroxisome proliferator-activated receptors gamma and delta signaling, as well as exerting effects on HIV-1 protein Vpr. It inhibits Protobothrops flavoviridis venom-induced hemorrhagic lesions in ddY mice with an IC50 of 240.0 nM and has a dissociation constant with a pKa of 3.42. Toxicologically, the pLD50 in orally dosed rats is reported as 7.58, indicating a lethal dose for half of the test population. Despite its myriad activities, 4-Nitrobenzoic acid shows limited inhibition (6.0%) of recombinant human IDO1 using L-tryptophan as a substrate. It also affects mollusc neuronal membrane potential with a fold change of -0.52 relative to salicylic acid at pH 7.8. Further research from DrugMatrix highlights 4-Nitrobenzoic acid's influence on various physiological systems, including liver (ALT, ALP, AST), kidney (BUN), electrolyte balance (CO2, chloride, potassium, sodium), lipid metabolism (cholesterol, lipase), and blood cell counts (RBC, WBC, platelets), suggesting comprehensive systemic effects..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	4-Nitrobenzoic acid (4Nitrobenzoic acid) is a pharmaceutical intermediate often found in the production of folic acid, DABA, PABA and dyes.
靶点活性	HT29 cells:8.4 µM, A549 cells:5.3 µM
别名	Nitrodracylic acid, Kyselina p-nitrobenzoova, 4-硝基苯甲酸, 4Nitrobenzoic acid, 4 Nitrobenzoic acid

化学信息

分子量	167.12
分子式	C₇H₅NO₄
CAS No.	62-23-7
Smiles	OC(=O)C1=CC=C(C=C1)[N+]([O-])=O
密度	1.61 g/cm3

储存&溶解度

存储

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度信息

DMSO: 55 mg/mL (329.1 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.9837 mL	29.9186 mL	59.8372 mL	299.1862 mL
5 mM	1.1967 mL	5.9837 mL	11.9674 mL	59.8372 mL
10 mM	0.5984 mL	2.9919 mL	5.9837 mL	29.9186 mL
20 mM	0.2992 mL	1.4959 mL	2.9919 mL	14.9593 mL
50 mM	0.1197 mL	0.5984 mL	1.1967 mL	5.9837 mL
100 mM	0.0598 mL	0.2992 mL	0.5984 mL	2.9919 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。