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N,N'-Diphenylguanidine

Name: N,N'-Diphenylguanidine
Brand: TargetMol
SKU: T20253
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.79%

货号 T20253Cas号 102-06-7

别名 二苯胍, NSC-3272, NSC3272, NSC 3272

N,N'-Diphenylguanidine (NSC-3272) 是一种生化剂。

N,N'-Diphenylguanidine

一键复制产品信息

很棒

纯度: 99.79%

货号 T20253 别名 二苯胍, NSC-3272, NSC3272, NSC 3272Cas号 102-06-7

N,N'-Diphenylguanidine (NSC-3272) 是一种生化剂。

规格	价格	库存	数量
25 g	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.79%

颜色: 白色

性状: Solid

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

N,N'-Diphenylguanidine AI Summary

N,N'-Diphenylguanidine is a versatile bioactive compound with multiple inhibitory activities and interactions across various biological targets. It primarily inhibits [^3H]MK-801 radioligand binding to N-methyl-D-aspartate (NMDA) receptors in rat brain membranes with an IC50 of 3450.0 nM and [^3H]DTG radioligand binding to sigma receptors in guinea pig brain membranes with an IC50 of 397.0 nM. Additionally, it demonstrates inhibitory activity against sigma receptors with [^3H]-(+)-3-PPP binding (IC50 = 400.0 nM) and against [^3H]-TCP binding to PCP receptors (IC50 = 3450.0 nM). The compound also shows significant bioactivity in modulating various biological pathways and enzymes, including the inhibition of Tyrosyl-DNA Phosphodiesterase (TDP1), Polymerase Iota, and CYP450 2D6 enzyme, along with interactions with Sigma1 and Sigma2 receptors. It demonstrates inhibitory effects on Norepinephrine Transporter and is involved in various signaling pathways such as NF-kB, PXR, AhR, vitamin D receptor, and estrogen receptor alpha. In terms of antiviral properties, N,N'-Diphenylguanidine inhibits the cytotoxicity of cells infected with SARS-CoV-2 with effectiveness indicated by an IC50 value greater than 20000.0 nM and an observed inhibition of -6.79% in Caco-2 cells at 10 µM after 48 hours. It also shows a 15.31% inhibition rate of the SARS-CoV-2 3CL-Pro protease at a concentration of 20 µM, indicating potential antiviral activity. Moreover, N,N'-Diphenylguanidine exhibits moderate inhibition of human HDAC6 with a 15.46% inhibition rate using a commercial peptide substrate, highlighting its potential as a multifaceted agent in therapeutic research..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	N,N'-Diphenylguanidine (NSC-3272) is an agent of biochemical.
别名	二苯胍, NSC-3272, NSC3272, NSC 3272

化学信息

分子量	211.26
分子式	C₁₃H₁₃N₃
CAS No.	102-06-7
Smiles	N=C(NC1=CC=CC=C1)NC1=CC=CC=C1
密度	Ca. 0.348. Temperature:20 °C.

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 65 mg/mL (307.68 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7335 mL	23.6675 mL	47.3350 mL	236.6752 mL
5 mM	0.9467 mL	4.7335 mL	9.4670 mL	47.3350 mL
10 mM	0.4734 mL	2.3668 mL	4.7335 mL	23.6675 mL
20 mM	0.2367 mL	1.1834 mL	2.3668 mL	11.8338 mL
50 mM	0.0947 mL	0.4734 mL	0.9467 mL	4.7335 mL
100 mM	0.0473 mL	0.2367 mL	0.4734 mL	2.3668 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

N,N'-Diphenylguanidine N,N'Diphenylguanidine N,N' Diphenylguanidine

N,N'-Diphenylguanidine

N,N'-Diphenylguanidine