Exifone

Name: Exifone
Brand: TargetMol
SKU: T20080
Price: 195 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.95%

货号 T20080Cas号 52479-85-3

别名 依昔苯酮, NSC-680919, NSC680919, NSC 680919

Exifone (NSC-680919) 是一种混合的、非必需的 HDAC1 激活剂，能够与游离酶和底物结合酶结合，从而提高 HDAC1 催化的去乙酰化的相对最大速率。

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Exifone

一键复制产品信息

很棒

纯度: 99.95%

货号 T20080 别名 依昔苯酮, NSC-680919, NSC680919, NSC 680919Cas号 52479-85-3

Exifone (NSC-680919) 是一种混合的、非必需的 HDAC1 激活剂，能够与游离酶和底物结合酶结合，从而提高 HDAC1 催化的去乙酰化的相对最大速率。

规格	价格	库存
5 mg	¥ 287	现货
25 mg	¥ 513	现货
50 mg	¥ 769	现货
100 mg	¥ 1,154	现货
200 mg	¥ 1,731	现货
1 mL x 10 mM (in DMSO)	¥ 195	现货

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COA HNMR LCMS 产品操作手册

产品介绍

Exifone AI Summary

Exifone exhibits neurotoxicity on murine HT-22 hippocampal cell culture at maximum tolerated concentrations of 10.0 µM (MTT reduction assay) and 50.0 µM (LDH assay), and TC50 values of 34.0 µM and 91.0 µM respectively in vitro. Despite this, it shows neuroprotective activity against L-homocysteic acid cytotoxicity with a PC50 value above 10.0 µM in both assays. It has also been identified as DILI positive in the Drug Induced Liver Injury Prediction System (DILIps) validation dataset with a score of 1.0, indicating potential for drug-induced liver injury. Additionally, the compound demonstrates moderate and acute liver toxicity, including severe hepatitis and cytolytic liver toxicity. In bioactivity assays, Exifone shows antiviral properties by inhibiting SARS-CoV-2 induced cytotoxicity in Vero E6 cells and Caco-2 cells, albeit with varying inhibition percentages. It has shown potent inhibition of SARS-CoV-2 3CL-Pro protease with an inhibition percentage of 90.77% at a 20 µM concentration and an IC50 value of 4380.0 nM, but no significant inhibition of MERS 3CL-Pro protease. Other antiviral bioactivity includes blocking Ebola virus entry with an AC50 of 1778.3 nM and exhibiting IC50 values from 69.11 nM to 192.37 nM in various cell viability assays. Furthermore, Exifone inhibits human HDAC6 enzyme activity, with 17.44% inhibition in an enzymatic assay using a commercial peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Exifone (NSC-680919) is a mixed, nonessential activator of HDAC1 that is capable of binding to both free and substrate-bound enzyme, resulting in an increased relative maximal rate of HDAC1-catalyzed deacetylation.
别名	依昔苯酮, NSC-680919, NSC680919, NSC 680919

化学信息

分子量	278.21
分子式	C₁₃H₁₀O₇
CAS No.	52479-85-3
Smiles	C(=O)(C1=CC(O)=C(O)C(O)=C1)C2=C(O)C(O)=C(O)C=C2
密度	1.759 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (898.6 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5944 mL	17.9720 mL	35.9441 mL	179.7204 mL
5 mM	0.7189 mL	3.5944 mL	7.1888 mL	35.9441 mL
10 mM	0.3594 mL	1.7972 mL	3.5944 mL	17.9720 mL
20 mM	0.1797 mL	0.8986 mL	1.7972 mL	8.9860 mL
50 mM	0.0719 mL	0.3594 mL	0.7189 mL	3.5944 mL
100 mM	0.0359 mL	0.1797 mL	0.3594 mL	1.7972 mL