TNFα

SPD304 是一种选择性 TNF-α 抑制剂，可阻断 TNF 与其受体的相互作用。 SPD304 在体外抑制 TNF 受体 1 与 TNF-α 结合的 IC50 为 22 µM。

SPD304 dihydrochloride 是 TNF-α 的特异性抑制剂，IC50 为 22 µM。 SPD304 dihydrochloride 促进 TNF 三聚体的解离。

TNF-α (31-45), human acetate(144796-71-4 free base) 是一种肿瘤坏死因子-α 的肽。

Mirtazapine (6-Azamianserin) 是一种有效的具有口服活性的去甲肾上腺素能和特异性血清素能抗抑郁剂 (NaSSA)。它也是一种5-HT2、5-HT3、组胺 H1 受体和 α2-肾上腺素受体拮抗剂，pKi 值分别为 8.05、8.1、9.3 和 6.95。

Human TNF alpha (46-65) peptide.

TNF-α (31-45), human, is a peptide of tumor necrosis factor-α.

TNF-α-IN-14是一种有效且选择性的TNFα抑制剂，IC50值为1.1 µM，具有抗炎特性(WO2001072735A2; compound 12)。

GSK2245035 is a highly selective intranasal TLR7 agonist with preferential Type-1 interferon (IFN)-stimulating properties (pEC50s: 9.3 and 6.5 for IFNα and TFNα). It effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood

TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α's recruitment and activation of osteoclasts. TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destruction.

TNF-α-IN-16 是一款有效的 TNFα 抑制剂，其 IC50 值小于 0.6 μM，并且具有抗炎特性 (WO2001072735A2；example 18)。

TNF-α-IN-2 is a highly potent and orally bioavailable inhibitor of tumor necrosis factor alpha (TNFα), exhibiting an IC50 of 25 nM in the HTRF assay. It exerts its inhibitory effects by inducing conformational changes in the TNFα trimer upon binding, resulting in disrupted signaling when the trimer interacts with TNFR1. TNF-α-IN-2 holds promise as a valuable tool for investigating the pathogenesis of rheumatoid arthritis[1].

TNF-α (10-36), human acetate 是一种肿瘤坏死因子-α 的肽。

TNF-α (10-36), human (TFA) is a peptide of human TNF-α.

TNF-α (46-65), human (TFA) is a peptide of human TNF-α.

TNF-α (10-36), human, is a potent pro-inflammatory cytokine involved in the acute phase stress response.

TNF-α-IN-13, a potent inhibitor of TNFα, exhibits an IC 50 of less than 0.6 μM and possesses antiinflammatory properties ( example 6) [1].

TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα ( K D = 6.8 nM).

TNF-α-IN-12 作为一种效能显著的TNF-α抑制剂，其IC50值为0.1 μM，能有效降低血液中TNF-α的水平。

TNF-α IL-1β-IN-1 (compound 11a) 作为一种有效的抗炎化合物，可有效降低TNF-α和IL-1β的活性并抑制氧化应激及心肌细胞凋亡。此外，该化合物对于脓毒性心肌损伤显示出显著的治疗效果，并能改善心肌的血流供应。

TNF IFNγ-IN-1(TGA) 是 TNF 和 IFN-γ 的双重抑制剂。TNF IFNγ-IN-1 具有潜在的抗氧化和抗炎活性，可用于类似阿尔茨海默等的神经退行性疾病。

TAPI-2 is a broad-spectrum inhibitor of MMP (IC50: 20 μM), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM).

TNF-α-IN-8 (compound I-42) 作为一种TNF-α抑制剂，属于异吲哚-亚胺类化合物，适用于肿瘤、心脏病、骨质疏松、炎症、过敏及自身免疫性疾病的研究。作为点击化学试剂，其Azide基团能与含Alkyne的分子配对，通过铜催化的叠氮－炔环加成反应(CuAAc)产生反应，也可与含DBCO或BCN基团的分子进行菌株促进的炔－叠氮环加成反应(SPAAC)。

Anti-TNF-alpha Antibody (5Z310) 是一种靶向人 TNF-alpha 的单克隆抗体，是一种 Mouse IgG1 抗体。

Anti-Mouse?TNF-alpha TNFSF2 Antibody (XT3.11) 是一种源自小鼠的IgG1类抗体，专门针对TNF-alpha TNFSF2进行靶向。其同型对照为RatIgG1kappa, Isotype Control。