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Anti-GITR/TNFRSF18 Polyclonal Antibody

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货号 TMAB-00771

别名 tumor necrosis factor receptor superfamily, member 18, GITR-D, GITR, CD357, AITR

Anti-GITR/TNFRSF18 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GITR/TNFRSF18。Anti-GITR/TNFRSF18 Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P。

Anti-GITR/TNFRSF18 Polyclonal Antibody

Anti-GITR/TNFRSF18 Polyclonal Antibody

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货号 TMAB-00771 别名 tumor necrosis factor receptor superfamily, member 18, GITR-D, GITR, CD357, AITR

Anti-GITR/TNFRSF18 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GITR/TNFRSF18。Anti-GITR/TNFRSF18 Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-GITR/TNFRSF18 Polyclonal Antibody is a Rabbit antibody targeting GITR/TNFRSF18. Anti-GITR/TNFRSF18 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P.
别名tumor necrosis factor receptor superfamily, member 18, GITR-D, GITR, CD357, AITR
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat)
验证活性
Tissue/cell: human oral squamous cell carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer (0.01M, pH6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37°C for 20 min;
Incubation: Anti-TNFRSF18 Polyclonal Antibody, Unconjugated (TMAB-00771) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody and DAb staining.
应用IFIHC-FrIHC-P
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.
组织特异性Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景TNFRSF18 or GITR (glucocorticoid-induced TNF receptor family-regulated gene) is a 25 kD TNF receptor superfamily member (also known as AITR and TNFRSF18) originally identified in the mouse by comparing untreated and dexamethasone-treated murine T cell hybridoma cells. Human GITR was subsequently identified by searching an expressed sequence tag database. GITR is expressed on activated lymphocytes and is upregulated by T cell receptor engagement. The cytoplasmic domain of GITR is homologous to CD40, 4-1BB and CD27 and has been shown to interact with TRAF 1-3, but not TRAF 5 or 6. GITR signaling has been shown to regulate T cell proliferation and TCR-mediated apoptosis, and to break immunological self-tolerance. GITR appears to be highly expressed on CD4+CD25+ T regulatory cells and has been shown to induce NF-kB activation through TRAF2/NIK signaling. GITR has been proposed to be involved in the development of regulatory T cells and to regulate the activity of Th1 subsets. GITR binds GITRL, a TNF superfamily ligand expressed on endothelial cells, dendritic cells, macrophages, and B cells.
抗原信息
免疫原
KLH conjugated synthetic peptide: mouse TNFRSF18
抗原种属
Mouse
基因名称
TNFRSF18
基因ID
21936
蛋白名称
Tumor necrosis factor receptor superfamily member 18
Uniprot ID
O35714
研究领域
TNF,Regulatory T Cells,Necrosis Factors,TNF
功能
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
化学信息
分子量Theoretical: 24 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

  • 稀释 计算器
  • 配液 计算器

关键词

CD-357CD 357
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