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TNF RII Protein, Human, Recombinant (mFc)

TNF RII Protein, Human, Recombinant (mFc)

产品编号 TMPJ-00288
别名: Tumor necrosis factor receptor 2, TNFRSF1B, p75, TNF-RII, TNF-R2, Tumor necrosis factor receptor type II, p80 TNF-α receptor, CD120b, p80 TNF-alpha receptor, Tumor necrosis factor receptor superfamily member 1B

TNF RII Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 60 KDa and the accession number is P20333.

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TNF RII Protein, Human, Recombinant (mFc)
规格 价格/CNY 货期 数量
10 μg ¥ 820 5日内发货
50 μg ¥ 2,480 5日内发货
500 μg ¥ 12,100 5日内发货
1 mg ¥ 17,400 5日内发货
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产品目录号及名称: TNF RII Protein, Human, Recombinant (mFc) (TMPJ-00288)
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生物活性
技术参数
产品性质
生物活性 1. Loaded Human TNF alpha-His on HIS1K Biosensor, can bind Human TNF RII-mFc with an affinity constant of 1.83 nM as determined in BLI assay. (Regularly tested)  2. Immobilized Recombinant Human TNF RII-mFc at 1μg/ml (100 μl/well) can bind Recombinant Human TNF alpha-His. The ED50 of Recombinant Human TNF alpha-His is 1.97 ng/ml. (Regularly tested)
产品描述 TNF RII Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 60 KDa and the accession number is P20333.
种属 Human
表达系统 HEK293 Cells
标签 C-mFc
蛋白编号 P20333
别名 Tumor necrosis factor receptor 2, TNFRSF1B, p75, TNF-RII, TNF-R2, Tumor necrosis factor receptor type II, p80 TNF-α receptor, CD120b, p80 TNF-alpha receptor, Tumor necrosis factor receptor superfamily member 1B
氨基酸序列 Pro24-Thr206
蛋白构建 Pro24-Thr206
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 60 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) is a member of the tumor necrosis factor receptor superfamily. Human TNF RII contains four cysteinerich repeats in its ECD, which shares 58% and 56% amino acid sequence identity with the mouse and rat orthologs, respectively.TNF RII is expressed predominantly on cells of the hematopoietic lineage, such as T and natural killer cells, as well as on endothelial cells, microglia, astrocytes,neurons, oligodendrocytes, cardiac myocytes, thymocytes, and mesenchymal stem cells.TNF RII binds to the membranebound forms of TNFα and Lymphotoxinα/TNFβ;soluble TNF is thought to signal predominately through TNF RI.Soluble TNF RII is believed to inhibit TNF biological activity by binding TNF thereby preventing it from activating membrane TNF receptors.

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Keywords

TNF RII Protein, Human, Recombinant (mFc) Tumor necrosis factor receptor 2 TNFRSF1B p75 TNF-RII TNF-R2 Tumor necrosis factor receptor type II p80 TNF-α receptor CD120b p80 TNF-alpha receptor p80 TNF-a receptor Tumor necrosis factor receptor superfamily member 1B recombinant recombinant-proteins proteins protein

 

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