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Anti-4-1BB Ligand/TNFSF9 Antibody-PerCP (8F465) 是一种 PerCP-conjugated Rabbit 抗体,靶向 4-1BB Ligand/TNFSF9。Anti-4-1BB Ligand/TNFSF9 Antibody-PerCP (8F465) 可用于 FCM。
Anti-4-1BB Ligand/TNFSF9 Antibody-PerCP (8F465) 是一种 PerCP-conjugated Rabbit 抗体,靶向 4-1BB Ligand/TNFSF9。Anti-4-1BB Ligand/TNFSF9 Antibody-PerCP (8F465) 可用于 FCM。
产品描述 | Anti-4-1BB Ligand/TNFSF9 Antibody-PerCP (8F465) is a PerCP-conjugated Rabbit antibody targeting 4-1BB Ligand/TNFSF9. Anti-4-1BB Ligand/TNFSF9 Antibody-PerCP (8F465) can be used in FCM. |
Ig Type | Monoclonal Rabbit IgG |
克隆号 | 8F465 |
交叉反应 | Mouse |
验证活性 | Profile of anti-TNFSF9 reactivity on Raw264.7 cells analyzed by flow cytometry. Cells should be Fc-blocked by treatment with Mouse BD Fc Block™ purified anti-CD16/CD32 mAb 2.4G2 prior to staining, washed, then stained with PerCP Rabbit anti-TNFSF9. |
应用 | FCM |
推荐剂量 | 10 μl/Test, 0.1 mg/ml |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse 4-1BBL / CD137L / TNFSF9 (rM 4-1BBL / CD137L / TNFSF9; TMPY-00959; NP_033430.1; Arg 104-Glu 309) and conjugated with PerCP under optimum conditions, the unreacted PerCP was removed. |
纯化方式 | Protein A |
性状 | Liquid |
缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
研究背景 | 4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as dendritic cells, macrophages, and activated B cells. Members of the TNF-TNF receptor superfamily have been shown to play critical roles in regulating cellular activation, differentiation and apoptosis. Several studies have reported that 4-1BBL/4-1BB interaction provided a co-stimulatory signal to T cells, and increased T cell proliferation and cytokines production. In addition, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: ICC AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
偶联 | PerCP |
其他可选修饰符 | Unconjugated/APC/FITC/PE |
可提供抗体种类 | 5 |
免疫原 | Recombinant Mouse 4-1BBL / CD137L / TNFSF9 protein (TMPY-00959) |
抗原种属 | Mouse |
研究领域 | Cancer Drug Targets |
储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
运输方式 | Shipping with blue ice. |
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