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CD30/TNFRSF8 Protein, Human, Recombinant (His), Biotinylated

产品编号 TMPY-05118

别名: D1S166E, Ki-1, tumor necrosis factor receptor superfamily, member 8, CD30

CD30/TNFRSF8 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.9 kDa and the accession number is P28908-1.

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CD30/TNFRSF8 Protein, Human, Recombinant (His), Biotinylated

规格	价格/CNY		货期	数量
20 μg	￥ 1,950		5日内发货
100 μg	￥ 4,620		5日内发货

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生物活性	Testing in progress
产品描述	CD30/TNFRSF8 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.9 kDa and the accession number is P28908-1.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	P28908-1
别名	D1S166E, Ki-1, tumor necrosis factor receptor superfamily, member 8, CD30
蛋白构建	The TNFRSF8 (NP_001234.2) (Met1-Lys379) was expressed with a C-terminal polyhistidine tag. The purified protein was biotinylated in vitro.
蛋白纯度	> 90 % as determined by SDS-PAGE.
分子量	39.9 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing Sterile PBS. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated, but not resting, T and B cells. CD30 can regulate proliferation of lymphocytes and may also play an important role in human immunodeficiency virus replication. As a regulator of apoptosis, CD30 protein induces cell death or proliferation, depending on the cell type, and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. CD30 protein expression is upregulated in various hematological malignancies, including Reed-Sternberg cells in Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL) and subsets of Non-Hodgkin's lymphomas (NHLs), and CD30 is also linked to leukocytes in patients with chronic inflammatory diseases, including lupus erythematosus, asthma, rheumatoid arthritis and atopic dermatitis (AD).Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Rossi FM,et al.(2001) CD30L up-regulates CD30 and IL-4 expression by T cells. FEBS Lett. 508(3): 418-22. 2. Trovato M, et al. (2001) Expression of CD30 ligand and CD30 receptor in normal thyroid and benign and malignant thyroid nodules. Thyroid. 11(7): 621-8. 3. Ekstrom ES,et al.(2001) Presence of CD30(+) and CD30L(+) cells in human placenta and soluble CD30 levels in cord blood are independent of maternal atopy. Placenta. 22(4): 372-9. 4. Tang C,et al.(2008) A novel role of CD30L/CD30 signaling by T-T cell interaction in Th1 response against mycobacterial infection. J Immunol. 181(9): 6316-27. 5. Sun X,et al.(2008) A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice. Gastroenterology. 134(2): 447-58. 6. Oflazoglu E,et al.(2009) Targeting CD30/CD30L in Oncology and Autoimmune and Inflammatory Diseases.Adv Exp Med Biol. 647: 174-85.

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Keywords

CD30/TNFRSF8 Protein, Human, Recombinant (His), Biotinylated D1S166E CD 30 Ki-1 tumor necrosis factor receptor superfamily, member 8 CD30 CD-30 recombinant recombinant-proteins proteins protein

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