4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc & His)

Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pass type I membrane protein which contains 4 TNFR-Cys repeats. The human and mouse proteins share 60% amino acid sequence identity. It is absent from naive T cells, but upregulated and continually expressed following T cell activation. It is a receptor for TNFSF9/4-1BBL, and possibly active during T cell activation. 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc & His) is expressed in HEK293 mammalian cells with C-Fc-6xHis tag. The predicted molecular weight is 55-75 KDa and the accession number is Q07011.

规格	价格/CNY		数量
10 μg	￥ 780	5日内发货
50 μg	￥ 1,650	5日内发货
500 μg	￥ 10,200	5日内发货
1 mg	￥ 16,600	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 780

5日内发货

50 μg

￥ 1,650

5日内发货

500 μg

￥ 10,200

5日内发货

1 mg

￥ 16,600

5日内发货

生物活性

1. Loaded Human 4-1BB-Fc-His on HIS1K Biosensor, can bind Anti-Human CD137 mAb with an affinity constant of 12.2 nM as determined in BLI assay. (Regularly tested) 2. Immobilized Human 4-1BB-Fc-His at 2μg/ml (100 μl/well)can bind Anti-Human CD137 mAb. The ED50 of Anti-Human CD137 mAb is 0.41ug/ml. (Regularly tested)

产品描述

种属	Human
表达系统	HEK293 Cells
标签	C-hFc-6xHis
蛋白编号	Q07011
别名	CD137, 4-1BB ligand receptor, T-cell antigen 4-1BB homolog, T-cell antigen ILA, ILA, CDw137, TNFRSF9
氨基酸序列	Leu24-Gln186
蛋白构建	Leu24-Gln186
分子量	55-75 KDa, reducing conditions

内毒素	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pass type I membrane protein which contains 4 TNFR-Cys repeats. The human and mouse proteins share 60% amino acid sequence identity. It is absent from naive T cells, but upregulated and continually expressed following T cell activation. It is a receptor for TNFSF9/4-1BBL, and possibly active during T cell activation.

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4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc & His)

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