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Anti-DR4/TRAIL R1 Antibody-PE (6F81)
还可以产品编号 TMAY-00778P
Anti-DR4/TRAIL R1 Antibody-PE (6F81) 是一种 PE-conjugated Mouse 抗体，靶向 DR4/TRAIL R1。Anti-DR4/TRAIL R1 Antibody-PE (6F81) 可用于 FCM。
Anti-DR4/TRAIL R1 Antibody-PE (6F81)
Anti-DR4/TRAIL R1 Antibody-PE (6F81)
还可以产品编号 TMAY-00778P
Anti-DR4/TRAIL R1 Antibody-PE (6F81) 是一种 PE-conjugated Mouse 抗体，靶向 DR4/TRAIL R1。Anti-DR4/TRAIL R1 Antibody-PE (6F81) 可用于 FCM。
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偶联与修饰
抗原信息
| 产品描述 | Anti-DR4/TRAIL R1 Antibody-PE (6F81) is a PE-conjugated Mouse antibody targeting DR4/TRAIL R1. Anti-DR4/TRAIL R1 Antibody-PE (6F81) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 6F81 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of human TNFRSF10A(CD261) expression on HeLa cells. HeLa cells were stained with PE-conjugated anti-Human TNFRSF10A(CD261). The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TRAIL R1 / CD261 / TNFRSF10A (rh TRAIL R1 / CD261 / TNFRSF10A; TMPY-01720; NP_003835.2; Met1-Asn239) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | Tumor necrosis factor receptor superfamily, member 10a (TRAIL R1), also known as TRAIL receptor 1 (TRAIL R1) or CD261 antigen, is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R1/CD261/TNFRSF10A serves as a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAIL R1 can promote the activation of NF-kappa-B. TRAIL R1/CD261/TNFRSF10A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | PE |
| 其他可选修饰符 | Unconjugated/FITC |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Human TRAIL R1 / CD261 / TNFRSF10A protein (TMPY-01720) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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