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Anti-TRAIL/TNFSF10 Antibody (2R399)
还可以产品编号 TMAY-00782
Anti-TRAIL/TNFSF10 Antibody (2R399) 是一种 Mouse 抗体，靶向 TRAIL/TNFSF10。Anti-TRAIL/TNFSF10 Antibody (2R399) 可用于 ELISA,ELISA(Cap)。
Anti-TRAIL/TNFSF10 Antibody (2R399)
Anti-TRAIL/TNFSF10 Antibody (2R399)
还可以产品编号 TMAY-00782
Anti-TRAIL/TNFSF10 Antibody (2R399) 是一种 Mouse 抗体，靶向 TRAIL/TNFSF10。Anti-TRAIL/TNFSF10 Antibody (2R399) 可用于 ELISA,ELISA(Cap)。
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产品介绍
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抗原信息
| 产品描述 | Anti-TRAIL/TNFSF10 Antibody (2R399) is a Mouse antibody targeting TRAIL/TNFSF10. Anti-TRAIL/TNFSF10 Antibody (2R399) can be used in ELISA,ELISA(Cap). |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 2R399 |
| 交叉反应 | Human |
| 应用 | ELISA,ELISA(Cap) |
| 推荐剂量 | ELISA: 1:1000-1:2000; ELISA(Cap): 1:250-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TNFSF10 / TRAIL / APO-2L (CD253) (rh TNFSF10 / TRAIL / APO-2L (CD253); NP_003801.1Val114-Gly281). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Tumor necrosis factor ligand superfamily member 10 (TNFSF10), also known as TNF-related apoptosis-inducing ligand (TRAIL), Apo-2 ligand, and CD253, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TNFSF10 / Apo-2L / CD253 functions as a ligand that induces the process of cell death called apoptosis. TNFSF10 / TRAIL shows homology to other members of the tumor necrosis factor superfamily. As one member of the cluster of differentiation system, TNFSF10 / CD253 is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion TNFSF10 / Apo-2L / CD253 / TRAIL binds to several members of TNF receptor superfamily including TNFRSF10A / TRAILR1, TNFRSF10B / TRAILR2, TNFRSF10C / TRAILR3, TNFRSF10D / TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of TNFSF10 / TRAIL may be modulated by binding to the decoy receptors TNFRSF10C / TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8 / JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human TNFSF10 / TRAIL / APO-2L (CD253) Protein |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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