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OX40/TNFRSF4 Protein, Mouse, Recombinant (rFc)

产品编号 TMPY-04993

别名: Txgp1, tumor necrosis factor receptor superfamily, member 4, CD134, ACT35, TXGP1L, Ly-70, Ox40

OX40/TNFRSF4 Protein, Mouse, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 47.3 kDa and the accession number is B1ASL3.

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OX40/TNFRSF4 Protein, Mouse, Recombinant (rFc)

规格	价格/CNY		货期	数量
100 μg	￥ 3,820		5日内发货
1 mg	￥ 20,800		5日内发货

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生物活性	Testing in progress
产品描述	OX40/TNFRSF4 Protein, Mouse, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 47.3 kDa and the accession number is B1ASL3.

种属	Mouse
表达系统	HEK293 Cells
标签	C-rFc
蛋白编号	B1ASL3
别名	Txgp1, tumor necrosis factor receptor superfamily, member 4, CD134, ACT35, TXGP1L, Ly-70, Ox40
蛋白构建	The Mouse Tnfrsf4 (NP_035789.1) (Met1-Pro211) was expressed with the Fc region of rabbit IgG at the C-terminus.
蛋白纯度	> 85 % as determined by SDS-PAGE.
分子量	47.3 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy

参考文献

1. Compaan D.M., et al. (2006) . The crystal structure of the costimulatory OX40-OX40L complex. Structure 14:1321-1330. 2. Kawamata S., et al. (1998). Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation. J. Biol. Chem. 273:5808-5814. 3. Byun M., (2013) Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. J. Exp. Med. 210:1743-1759.

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Keywords

OX40/TNFRSF4 Protein, Mouse, Recombinant (rFc) ACT 35 CD-134 ACT-35 Txgp1 tumor necrosis factor receptor superfamily, member 4 CD134 ACT35 TXGP1L Ly-70 CD 134 Ox40 recombinant recombinant-proteins proteins protein

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