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顶部生物活性储存和溶解信息计算器

Anti-DR5/TRAIL R2 Antibody (3K136)

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Anti-DR5/TRAIL R2 Antibody (3K136)
产品编号 TMAY-00864
别名 ZTNFR9, tumor necrosis factor receptor superfamily, member 10b, TRICKB, TRICK2B, TRICK2A, TRICK2, TRAIL-R2, TRAILR2, KILLER/DR5, KILLER, DR5, CD262

Anti-DR5/TRAIL R2 Antibody (3K136) 是一种 Rabbit 抗体，靶向 DR5/TRAIL R2。Anti-DR5/TRAIL R2 Antibody (3K136) 可用于 ELISA,FCM。

Anti-DR5/TRAIL R2 Antibody (3K136)

Anti-DR5/TRAIL R2 Antibody (3K136)

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Anti-DR5/TRAIL R2 Antibody (3K136)
产品编号 TMAY-00864 别名 ZTNFR9, tumor necrosis factor receptor superfamily, member 10b, TRICKB, TRICK2B, TRICK2A, TRICK2, TRAIL-R2, TRAILR2, KILLER/DR5, KILLER, DR5, CD262

Anti-DR5/TRAIL R2 Antibody (3K136) 是一种 Rabbit 抗体，靶向 DR5/TRAIL R2。Anti-DR5/TRAIL R2 Antibody (3K136) 可用于 ELISA,FCM。

规格价格库存数量
100 μL
¥ 2,279
5日内发货
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产品介绍

生物活性
产品描述
Anti-DR5/TRAIL R2 Antibody (3K136) is a Rabbit antibody targeting DR5/TRAIL R2. Anti-DR5/TRAIL R2 Antibody (3K136) can be used in ELISA,FCM.
别名ZTNFR9, tumor necrosis factor receptor superfamily, member 10b, TRICKB, TRICK2B, TRICK2A, TRICK2, TRAIL-R2, TRAILR2, KILLER/DR5, KILLER, DR5, CD262
Ig Type
Rabbit IgG
克隆号
3K136
交叉反应
Human
验证活性
Flow cytometric analysis of Human TNFRSF10B(CD262) expression on Jurkat cells. Cells were stained with purified anti-Human TNFRSF10B(CD262), then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells.
应用
ELISA
FCM
推荐剂量
ELISA: 1:5000-1:10000; FCM: 1:25-1:100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human TNFRSF10B / CD262 extracellular domain (rh TNFRSF10B; TMPY-01185; Met 1-Glu 182; NP_003833.4).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, also known as Death receptor 5, CD262, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL R2), is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R2/CD262/TNFRSF10B was purified independently as the only receptor for TRAIL detectable on the surface of two different human cell lines that undergo apoptosis upon stimulation with TRAIL. TRAIL R2/CD262/TNFRSF10B contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain. TRAIL R2/CD262/TNFRSF10B mediates apoptosis via the intracellular adaptor molecule FADD/MORT1. TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family. Defects in TRAIL R2/CD262/TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) also known as squamous cell carcinoma of the head and neck.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
偶联与修饰
偶联
Unconjugated
其他可选修饰符
PE
可提供抗体种类
2
抗原信息
免疫原
Recombinant Protein: Human CD262 protein (TMPY-01185)
抗原种属
Human
研究领域
Cancer Drug Targets
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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关键词

ZTNFR-9ZTNFR 9TRICK-2TRICK 2TRAILR-2TRAILR 2DR-5DR 5CD-262CD 262

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