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4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant

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产品编号 TMPS-00157

4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant is expressed in E. coli. The accession number is Q07011.

4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant

一键复制产品信息

产品编号 TMPS-00157

4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant is expressed in E. coli. The accession number is Q07011.

规格	价格	库存
5 μg	¥ 882	6-8日内发货
10 μg	¥ 1,370	6-8日内发货
20 μg	¥ 2,160	5日内发货
50 μg	¥ 3,960	5日内发货
100 μg	¥ 6,280	5日内发货
200 μg	¥ 9,820	5日内发货
500 μg	¥ 18,500	5日内发货
1 mg	¥ 29,600	5日内发货

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产品信息

生物活性	Fully biologically active when compared to standard. The biological activity is determined by its inhibitory effect of IL-8 production using human peripheral blood mononuclear cells. About 90 % of inibition was seen using a concentration of 1.0 μg for both 4-1BB Ligand and 4-1BB Receptor.
产品描述	4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant is expressed in E. coli. The accession number is Q07011.
种属	Human
表达系统	E. coli
标签	Tag Free
蛋白编号	Q07011
别名	TNFRSF9,T-cell antigen ILA,CD137 antigen,4-1BB
蛋白构建	Glu18-Ser184
蛋白纯度	> 97% as determined by SDS-PAGE; > 97% as determined by HPLC
分子量	17.7 kDa (Predicted)
内毒素	< 1 EU/μg of protein by LAL method
缓冲液	Lyophilized from a 0.2 μm filtered solution in 10 mM PB, pH 8.0, 150 mM NaCl.
复溶方法	It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.
存储	Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	4-1BB(CD137) is a member of the tumor necrosis factor (TNF) receptor family. Mature human 4-1BB consists of a 163 amino acid extracellular domain (ECD) with four TNFR cysteine‑rich repeats, a 27 aa transmembrane segment, and a 42 aa cytoplasmic domain; 4-1BB (CD137) is expressed as a disulfide-linked homodimer on various populations of activated T cell including CD4 + , CD8 + , memory CD8 + , NKT, and regulatory T cells as well as on myeloid and mast cell progenitors, dendritic cells, mast cells, and bacterially infected osteoblasts. It binds with high affinity to the transmembrane 4-1BB Ligand/TNFSF9 which is expressed on antigen presenting cells and myeloid progenitor cells. This interaction co-stimulates the proliferation, activation, and/or survival of the 4-1BB expressing cell. It can also enhance the activation-induced cell death of repetitively stimulated T cells.