OX40L/TNFSF4 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 42.1 kDa and the accession number is A0A024R937.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 μg | ¥ 2,940 | 5日内发货 | ||
1 mg | ¥ 19,100 | 5日内发货 |
生物活性 | Measured by its binding ability in a functional ELISA. Immobilized recombinant Human TNFRSF4-His at 10 μg/ml (100 μl/well) can bind human S4-mFc3-TNFSF4 with a linear range of 1.28-20 μg/ml. |
产品描述 | OX40L/TNFSF4 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 42.1 kDa and the accession number is A0A024R937. |
种属 | Human |
表达系统 | HEK293 Cells |
标签 | N-mFc |
蛋白编号 | A0A024R937 |
别名 | TXGP1, CD252, OX-40L, OX4OL, GP34, tumor necrosis factor (ligand) superfamily, member 4, CD134L |
蛋白构建 | The Human TNFSF4 (NP_003317.1) (Gln51-Leu183) was expressed with the Fc region of Mouse IgG1 at the N-terminus. |
蛋白纯度 | > 90 % as determined by SDS-PAGE. |
分子量 | 42.1 kDa (predicted) |
内毒素 | < 1.0 EU/μg of the protein as determined by the LAL method. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
复溶方法 | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
存储 |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. |
研究背景 | OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX40. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD4-stimulated B cells, this cytokine along with CD7 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
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OX40L/TNFSF4 Protein, Human, Recombinant (mFc) TXGP1 CD252 OX-40L OX4OL GP-34 GP34 CD 252 CD-252 tumor necrosis factor (ligand) superfamily, member 4 TXGP 1 CD134L TXGP-1 GP 34 recombinant recombinant-proteins proteins protein