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Anti-BCMA/TNFRSF17 Antibody (1M731)

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产品编号 TMAY-01036

别名 tumor necrosis factor receptor superfamily member 17, TNFRSF13A, CD269, BCMA, BCM

Anti-BCMA/TNFRSF17 Antibody (1M731) 是一种 Rabbit 抗体，靶向 BCMA/TNFRSF17。Anti-BCMA/TNFRSF17 Antibody (1M731) 可用于 ELISA。

Anti-BCMA/TNFRSF17 Antibody (1M731)

Anti-BCMA/TNFRSF17 Antibody (1M731)

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产品编号 TMAY-01036 别名 tumor necrosis factor receptor superfamily member 17, TNFRSF13A, CD269, BCMA, BCM

Anti-BCMA/TNFRSF17 Antibody (1M731) 是一种 Rabbit 抗体，靶向 BCMA/TNFRSF17。Anti-BCMA/TNFRSF17 Antibody (1M731) 可用于 ELISA。

规格价格库存数量
20 μL
¥ 785
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100 μL
¥ 2,294
5日内发货
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产品介绍

生物活性
产品描述
Anti-BCMA/TNFRSF17 Antibody (1M731) is a Rabbit antibody targeting BCMA/TNFRSF17. Anti-BCMA/TNFRSF17 Antibody (1M731) can be used in ELISA.
别名tumor necrosis factor receptor superfamily member 17, TNFRSF13A, CD269, BCMA, BCM
Ig Type
Rabbit IgG
克隆号
1M731
交叉反应
Human
特异性
Human BCMA
应用ELISA
推荐剂量
ELISA: 1:5000-1:10000
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human BCMA / TNFRSF17 (rh BCMA / TNFRSF17; TMPY-04493; NP_001183.2; Met1-Ala54).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13BBAFF), and to lead to NF-kappaB and MAPK8/JNK activation. TNFRSF17/BCMA/CD269 also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. TNFRSF17/BCMA/CD269 is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of TNFRSF17 as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases. TNFRSF17/BCMA is a target of donor B-cell immunity in patients with myeloma who respond to DLI. Antibody responses to cell-surface BCMA may contribute directly to tumor rejection in vivo.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human BCMA / TNFRSF17 Protein (TMPY-04493)
抗原种属
Human
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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关键词

CD-269CD 269

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