TL1A/TNFSF15 Protein, Human, Recombinant (monomeric hFc) is expressed in HEK293 Cells. The accession number is O95150-1.

Human

HEK293 Cells

VEGI192A,VEGI,tumor necrosis factor (ligand) superfamily, member 15,TL1A,TL1

Leu72-Leu251

> 95% as determined by Tris-Bis PAGE; > 90% as determined by HPLC

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro and in vivo, and that death receptor 3 (DR3), a cell surface receptor of TNFSF15, mediates TNFSF15-induced dephosphorylation of VEGFR2.