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Anti-TNFAIP3 Polyclonal Antibody

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货号 TMAB-13624

Anti-TNFAIP3 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 TNFAIP3。Anti-TNFAIP3 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-TNFAIP3 Polyclonal Antibody

Anti-TNFAIP3 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-13624

Anti-TNFAIP3 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 TNFAIP3。Anti-TNFAIP3 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-TNFAIP3 Polyclonal Antibody is a Rabbit antibody targeting TNFAIP3. Anti-TNFAIP3 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Rat,Dog,Pig,Cow,Horse)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景A20 is a Cys2/Cys2 zinc finger protein that is induced by a variety of inflammatory stimuli and regulates gene expression. Specifically, A20 is induced by tumor necrosis factor (TNF) and interleukin 1 (IL-1), and acts as a negative regulator of nuclear factor κ B (NFκB) gene expression. By inhibiting NFκB activation, A20 plays a critical role in terminating NFκB responses to various stimuli. Although the C-terminal region of A20 contains seven zinc finger domains, only four of these domains are required for in vitro inhibition of TNF-induced NFκB activation. A20 also interacts with several other proteins, such as TRAF2, TRAF6 and IkB kinase (IKK) γ protein, and can thereby inhibit cell death. TXBP151, a novel A20-binding protein, may mediate the anti-apoptotic activity of A20. Involved in the negative feedback regulation of signal transduction, A20 and A20-binding proteins may be useful as novel therapeutic tools in the treatment of a variety of diseases
抗原信息
免疫原
KLH conjugated synthetic peptide: human TNFAIP3
抗原种属
Human
基因名称
TNFAIP3
基因ID
7128
蛋白名称
Tumor necrosis factor alpha-induced protein 3
Uniprot ID
P21580
功能
TNFAIP3 interacts with NAF1 and inhibits TNF induced NF kappa B dependent gene expression by interfering with a RIP or TRAF2 mediated transactivation signal. It inhibits programmed cell death, has a role in the function of the lymphoid system, and may contribute to the in vivo effects of TNF.
化学信息
分子量Theoretical: 90 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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