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4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (CHO, hFc)

产品编号 TMPS-00001

4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (CHO, hFc) is expressed in CHO Cells. The accession number is Q07011.

4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (CHO, hFc)

产品编号 TMPS-00001

4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (CHO, hFc) is expressed in CHO Cells. The accession number is Q07011.

规格	价格	库存	数量
50 μg	¥ 2,160	5日内发货
1 mg	¥ 21,600	5日内发货

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产品信息

生物活性	Measured by its binding ability in a ligand-receptor binding ELISA. When recombinant 4-1BB/CD137/TNFRSF9, hFc, Human is Immobilized at 1.0 µg/ml (100 µl/well), the concentration of recombinant human 4-1BB Ligand that produces 50% optimal binding response is found to be approximately 5.0-15.0 ng/ml.
产品描述	4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (CHO, hFc) is expressed in CHO Cells. The accession number is Q07011.
种属	Human
表达系统	CHO Cells
标签	hFc
蛋白编号	Q07011
别名	TNFRSF9,T-cell antigen ILA,CD137 antigen,4-1BB
蛋白构建	Leu24-Gln186
蛋白纯度	> 95% as determined by SDS-PAGE
分子量	55~60 kDa (Reducing conditions)
内毒素	< 0.2 EU/μg of protein as determined by the LAL method.
缓冲液	Lyophilized from a 0.2 μm filtered solution in PBS.
复溶方法	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储	Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	4-1BB(CD137) is a member of the tumor necrosis factor (TNF) receptor family. Mature human 4-1BB consists of a 163 amino acid extracellular domain (ECD) with four TNFR cysteine‑rich repeats, a 27 aa transmembrane segment, and a 42 aa cytoplasmic domain; 4-1BB (CD137) is expressed as a disulfide-linked homodimer on various populations of activated T cell including CD4 + , CD8 + , memory CD8 + , NKT, and regulatory T cells as well as on myeloid and mast cell progenitors, dendritic cells, mast cells, and bacterially infected osteoblasts. It binds with high affinity to the transmembrane 4-1BB Ligand/TNFSF9 which is expressed on antigen presenting cells and myeloid progenitor cells. This interaction co stimulates the proliferation, activation, and/or survival of the 4-1BB expressing cell. It can also enhance the activation-induced cell death of repetitively stimulated T cells.