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Anti-4-1BB/CD137/TNFRSF9 Antibody-FITC (1B772)
还可以产品编号 TMAY-00148F
Anti-4-1BB/CD137/TNFRSF9 Antibody-FITC (1B772) 是一种 FITC-conjugated Rabbit 抗体，靶向 4-1BB/CD137/TNFRSF9。Anti-4-1BB/CD137/TNFRSF9 Antibody-FITC (1B772) 可用于 FCM。
Anti-4-1BB/CD137/TNFRSF9 Antibody-FITC (1B772)
Anti-4-1BB/CD137/TNFRSF9 Antibody-FITC (1B772)
还可以产品编号 TMAY-00148F
Anti-4-1BB/CD137/TNFRSF9 Antibody-FITC (1B772) 是一种 FITC-conjugated Rabbit 抗体，靶向 4-1BB/CD137/TNFRSF9。Anti-4-1BB/CD137/TNFRSF9 Antibody-FITC (1B772) 可用于 FCM。
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| 产品描述 | Anti-4-1BB/CD137/TNFRSF9 Antibody-FITC (1B772) is a FITC-conjugated Rabbit antibody targeting 4-1BB/CD137/TNFRSF9. Anti-4-1BB/CD137/TNFRSF9 Antibody-FITC (1B772) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 1B772 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human CD137 expression on PHA-activated human whole blood lymphocytes. Cells were stained with FITC-conjugated anti-Human CD137. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human CD137 (rh CD137; TMPY-01743; NP_001552.2; Met1-Gln186) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| 研究背景 | CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+and CD8+T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor necrosis factor receptor–associated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses. In addition, CD137 and CD137L are expressed in different human primary tumor tissues, suggesting that they may influence the progression of tumors. Crosslinking of CD137 on activated T cells has shown promise in enhancing anti-tumor immune responses in murine models, and agonistic anti-CD137 antibodies are currently being tested in phase I clinical trials. Soluble forms of CD137 (sCD137) are generated by differential splicing. sCD137 can bind to CD137 ligand to antagonize the costimulatory activities of the membrane-bound CD137 and reduce T cell proliferation and IL-2 secretion.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| 偶联 | FITC |
| 其他可选修饰符 | Unconjugated/APC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human CD137 Protein (TMPY-01743) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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