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Anti-NGFR/p75NTR Antibody (4S343)
还可以产品编号 TMAY-02524
Anti-NGFR/p75NTR Antibody (4S343) 是一种 Rabbit 抗体，靶向 NGFR/p75NTR。Anti-NGFR/p75NTR Antibody (4S343) 可用于 ELISA,ICC/IF。
Anti-NGFR/p75NTR Antibody (4S343)
Anti-NGFR/p75NTR Antibody (4S343)
还可以产品编号 TMAY-02524
Anti-NGFR/p75NTR Antibody (4S343) 是一种 Rabbit 抗体，靶向 NGFR/p75NTR。Anti-NGFR/p75NTR Antibody (4S343) 可用于 ELISA,ICC/IF。
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抗原信息
| 产品描述 | Anti-NGFR/p75NTR Antibody (4S343) is a Rabbit antibody targeting NGFR/p75NTR. Anti-NGFR/p75NTR Antibody (4S343) can be used in ELISA,ICC/IF. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 4S343 |
| 交叉反应 | Human |
| 验证活性 | Immunofluorescence staining of NGFR in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-Human NGFR monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to Cytoplasm and Cell membrane. |
| 应用 | ELISA,ICC/IF |
| 推荐剂量 | ELISA: 1:5000-1:10000; ICC-IF: 1:20-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human NGFR (rh NGFR; TMPY-02615; P08138; Met1-Asn250). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Nerve growth factor receptors (NGFRs) belong to a large growth factor receptor family. NGFR includes two types of receptors: high-affinity nerve growth factor receptor and low-affinity nerve growth factor receptor. The high-affinity nerve growth factor receptor is also referred to as the Trk family whose members are bound by some neurotrophins with high affinity.Nerve growth factorbinds with TrkA after being released from target cells, the NGF / TrkA complex is subsequently trafficked back to the cell body. The Low-affinity nerve growth factor receptor also named p75 which binds with all kinds of neurotrophins with low affinity. All four kinds of neurotrophins, including Nerve growth factor, Brain-derived neurotrophic factor, Neurotrophin-3, and Neurotrophin-4 bind to the p75. Studies have proved that NGFR acts as a molecular signal switch that determines cell death or survival by three steps. First, pro-nerve growth factor (prNGF) triggers cell apoptosis by its high-affinity binding to p75NTR, while NGF induces neuronal survival with low-affinity binding. Second, p75NTR mediates cell death by combining with co-receptor Sortilin, whereas it promotes neuronal survival through combination with proNGF. Third, the release of the intracellular domain chopper or cleavage short p75 NTR can independently initiate neuronal apoptosis. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human NGFR Protein (TMPY-02615) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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