Benzydamine

Name: Benzydamine
Brand: TargetMol
SKU: T8807
Price: 268 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 98.34%

货号 T8807Cas号 642-72-8

别名 苄达明

Benzydamine 是一种苄基吲唑，具有镇痛、解热和抗炎作用。 Benzydamine 用于减少手术后和创伤后的疼痛和水肿，并促进愈合。

Benzydamine

一键复制产品信息

很棒

纯度: 98.34%

货号 T8807 别名 苄达明Cas号 642-72-8

Benzydamine 是一种苄基吲唑，具有镇痛、解热和抗炎作用。 Benzydamine 用于减少手术后和创伤后的疼痛和水肿，并促进愈合。

规格	价格	库存
5 mg	¥ 287	现货
50 mg	¥ 1,148	现货
100 mg	¥ 1,722	现货
1 mL x 10 mM (in DMSO)	¥ 268	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98.34%

联系我们获取更多批次信息

资源下载:

COA HPLC HNMR 产品操作手册

产品介绍

Benzydamine AI Summary

Benzydamine exhibits multifaceted bioactivity and physicochemical properties. It stimulates cyclic guanosine monophosphate (cGMP) levels with an EC50 of 1020.0 nM, notably activating bovine soluble guanylate cyclase (sGC) and inhibiting collagen-induced platelet aggregation with an IC50 of 6670.0 nM. The compound additionally acts as an inhibitor of various enzymes, including Human Jumonji Domain Containing 2E (JMJD2E) with an IC50 of 15848.9 nM, Cytochrome P450 2D6 (7943.3 nM), and 15-human lipoxygenase 2 (12589.3 nM). It also displays activity in several enzymatic and cellular assays, such as an AC50 of 5011.87 nM for p450-cyp1a2 and 7943.28 nM for p450-cyp2d6. Pharmacokinetic profiles reveal its human intestinal absorption rate, estimated by log10(%HIA +10) = 1.987, and intrinsic clearance rates in human hepatocytes (7.76 to 17.78 mL.min^-1.g^-1). Distribution potential is indicated by a LogD7.4 of 2.4 and a pKa of 9.27. Notably, Benzydamine shows no significant hepatic side effects according to the Drug Induced Liver Injury Prediction System. Despite low efficacy against human recombinant CYP2J2 (IC50 > 50000.0 nM) and moderate antiviral activity against SARS-CoV-2 in VERO-6 cells (IC50 > 20,000.0 nM), it maintains metabolic stability in human liver microsomes, with a half-life of 0.7183 hours and intrinsic clearance of 16.1 uL/min per mg protein. Additionally, the compound has shown inhibitory potential towards human HDAC6 enzyme, albeit weakly, and exhibits significant binding affinities towards various receptors, such as human SLC6A3 (AC50 112.7 nM), DRD3 (499.6 nM), and CHRM2 (3317.3 nM). It also demonstrates antagonist activity at CHRM1 (2297.3 nM) and ADRA1A (18919.1 nM), further contributing to its intricate pharmacological profile..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Benzydamine is a benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. Benzydamine is used to reduce post-surgical and post-traumatic pain and edema and to promote healing.
别名	苄达明

化学信息

分子量	309.41
分子式	C₁₉H₂₃N₃O
CAS No.	642-72-8
Smiles	C(N1C=2C(C(OCCCN(C)C)=N1)=CC=CC2)C3=CC=CC=C3
密度	1.08g/cm3
颜色	Transparent
物理性状	Liquid

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (145.44 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2320 mL	16.1598 mL	32.3196 mL	161.5979 mL
5 mM	0.6464 mL	3.2320 mL	6.4639 mL	32.3196 mL
10 mM	0.3232 mL	1.6160 mL	3.2320 mL	16.1598 mL
20 mM	0.1616 mL	0.8080 mL	1.6160 mL	8.0799 mL
50 mM	0.0646 mL	0.3232 mL	0.6464 mL	3.2320 mL
100 mM	0.0323 mL	0.1616 mL	0.3232 mL	1.6160 mL