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Benzydamine

Name: Benzydamine
Brand: TargetMol
SKU: T8807
Price: 268 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 苄达明

货号 T8807Cas号 642-72-8 一键复制产品信息纯度: 98.34%

很棒

Benzydamine 是一种苄基吲唑，具有镇痛、解热和抗炎作用。 Benzydamine 用于减少手术后和创伤后的疼痛和水肿，并促进愈合。

Benzydamine

一键复制产品信息

很棒

纯度: 98.34%

货号 T8807Cas号 642-72-8

别名 苄达明

Benzydamine 是一种苄基吲唑，具有镇痛、解热和抗炎作用。 Benzydamine 用于减少手术后和创伤后的疼痛和水肿，并促进愈合。

规格	价格	库存
5 mg	¥ 287	现货
50 mg	¥ 1,148	现货
100 mg	¥ 1,722	现货
1 mL x 10 mM (in DMSO)	¥ 268	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 98.34%

颜色: 白色

资源下载: COA HPLC HNMR产品操作手册

产品介绍

Benzydamine AI Summary

Benzydamine exhibits multifaceted bioactivity and physicochemical properties. It stimulates cyclic guanosine monophosphate (cGMP) levels with an EC50 of 1020.0 nM, notably activating bovine soluble guanylate cyclase (sGC) and inhibiting collagen-induced platelet aggregation with an IC50 of 6670.0 nM. The compound additionally acts as an inhibitor of various enzymes, including Human Jumonji Domain Containing 2E (JMJD2E) with an IC50 of 15848.9 nM, Cytochrome P450 2D6 (7943.3 nM), and 15-human lipoxygenase 2 (12589.3 nM). It also displays activity in several enzymatic and cellular assays, such as an AC50 of 5011.87 nM for p450-cyp1a2 and 7943.28 nM for p450-cyp2d6. Pharmacokinetic profiles reveal its human intestinal absorption rate, estimated by log10(%HIA +10) = 1.987, and intrinsic clearance rates in human hepatocytes (7.76 to 17.78 mL.min^-1.g^-1). Distribution potential is indicated by a LogD7.4 of 2.4 and a pKa of 9.27. Notably, Benzydamine shows no significant hepatic side effects according to the Drug Induced Liver Injury Prediction System. Despite low efficacy against human recombinant CYP2J2 (IC50 > 50000.0 nM) and moderate antiviral activity against SARS-CoV-2 in VERO-6 cells (IC50 > 20,000.0 nM), it maintains metabolic stability in human liver microsomes, with a half-life of 0.7183 hours and intrinsic clearance of 16.1 uL/min per mg protein. Additionally, the compound has shown inhibitory potential towards human HDAC6 enzyme, albeit weakly, and exhibits significant binding affinities towards various receptors, such as human SLC6A3 (AC50 112.7 nM), DRD3 (499.6 nM), and CHRM2 (3317.3 nM). It also demonstrates antagonist activity at CHRM1 (2297.3 nM) and ADRA1A (18919.1 nM), further contributing to its intricate pharmacological profile..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Benzydamine is a benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. Benzydamine is used to reduce post-surgical and post-traumatic pain and edema and to promote healing.
别名	苄达明

化学信息

分子量	309.41
分子式	C₁₉H₂₃N₃O
CAS No.	642-72-8
Smiles	C(N1C=2C(C(OCCCN(C)C)=N1)=CC=CC2)C3=CC=CC=C3
密度	1.08g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 250 mg/mL (807.99 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2320 mL	16.1598 mL	32.3196 mL	161.5979 mL
5 mM	0.6464 mL	3.2320 mL	6.4639 mL	32.3196 mL
10 mM	0.3232 mL	1.6160 mL	3.2320 mL	16.1598 mL
20 mM	0.1616 mL	0.8080 mL	1.6160 mL	8.0799 mL
50 mM	0.0646 mL	0.3232 mL	0.6464 mL	3.2320 mL
100 mM	0.0323 mL	0.1616 mL	0.3232 mL	1.6160 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Benzydamine

Benzydamine

Benzydamine

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引用文献

计算器

体内实验配液计算器

剂量转换

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