OX40L/TNFSF4 Protein, Mouse, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 44.4 kDa and the accession number is B6DXE3.
生物活性 | Testing in progress |
产品描述 | OX40L/TNFSF4 Protein, Mouse, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 44.4 kDa and the accession number is B6DXE3. |
种属 | Mouse |
表达系统 | HEK293 Cells |
标签 | N-rFc |
蛋白编号 | B6DXE3 |
别名 | Ath-1, TXGP1, tumor necrosis factor (ligand) superfamily, member 4, Ath1, Txgp1l, gp34, OX-40L, Ox40l, CD134L |
蛋白构建 | The Mouse Tnfsf4 ( NP_033478.1) (Gln49-Leu198) was expressed with the Fc region of rabbit IgG at the N-terminus.. |
蛋白纯度 | > 90 % as determined by SDS-PAGE. |
分子量 | 44.4 kDa (predicted) |
内毒素 | < 1.0 EU/μg of the protein as determined by the LAL method. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
复溶方法 | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
存储 |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. |
研究背景 | OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX40. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD4-stimulated B cells, this cytokine along with CD7 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
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OX40L/TNFSF4 Protein, Mouse, Recombinant (rFc) Ath-1 TXGP 1 TXGP1 tumor necrosis factor (ligand) superfamily, member 4 Ath1 Txgp1l gp34 OX-40L Ox40l TXGP-1 CD134L recombinant recombinant-proteins proteins protein