BCMA/TNFRSF17 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 38-45 KDa and the accession number is G7Q0I4.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 μg | ¥ 820 | 5日内发货 | ||
50 μg | ¥ 2,480 | 5日内发货 | ||
500 μg | ¥ 12,100 | 5日内发货 | ||
1 mg | ¥ 17,400 | 5日内发货 |
生物活性 | 1. Loaded Human APRIL-His on HIS1K Biosensor, can bind Cynomolgus BCMA-Fc with an affinity constant of 0.54 nM as determined in BLI assay. (Regularly tested) 2. Immobilized Human APRIL -Flag-His at 1μg/ml (100 μl/well) can bind Cynomolgus BCMA-Fc. The ED50 of Cynomolgus BCMA-Fc is 4.23 ng/ml. (Regularly tested) |
产品描述 | BCMA/TNFRSF17 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 38-45 KDa and the accession number is G7Q0I4. |
种属 | Cynomolgus |
表达系统 | Human Cells |
标签 | C-Fc |
蛋白编号 | G7Q0I4 |
别名 | Bcma, Tnfrsf17, B-cell maturation protein, Bcm, CD269, Tumor necrosis factor receptor superfamily member 17 |
氨基酸序列 | Met1-Ala53 |
蛋白构建 | Recombinant Cynomolgus B-cell Maturation Protein is produced by our Mammalian expression system and the target gene encoding Met1-Ala53 is expressed with a human IgG1 Fc tag at the C-terminus. |
蛋白纯度 | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 38-45 KDa, reducing conditions |
内毒素 | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
缓冲液 | Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCl, 100 mM Glycine, pH 7.5. |
复溶方法 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
存储 |
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
运输方式 |
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
研究背景 | B cell maturation antigen (BCMA) is a member of the TNF receptor superfamily. It has been designated TNFRSF17. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development,function and regulation. |
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BCMA/TNFRSF17 Protein, Cynomolgus, Recombinant (hFc) Bcma Tnfrsf17 B-cell maturation protein Bcm CD-269 CD269 Tumor necrosis factor receptor superfamily member 17 CD 269 recombinant recombinant-proteins proteins protein