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BAFF/TNFSF13B Protein, Human, Recombinant

产品编号 TMPY-02775

别名: CD257, BAFF, TNFSF20, ZTNF4, BLYS, THANK, TALL-1, TALL1, tumor necrosis factor (ligand) superfamily, member 13b, DTL

BAFF/TNFSF13B Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.2 kDa and the accession number is Q9Y275-1.

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BAFF/TNFSF13B Protein, Human, Recombinant

规格	价格/CNY		货期	数量
50 μg	￥ 2,940		5日内发货
1 mg	￥ 19,100		5日内发货

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生物活性	Testing in progress
产品描述	BAFF/TNFSF13B Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.2 kDa and the accession number is Q9Y275-1.

种属	Human
表达系统	E. coli
标签	Tag Free
蛋白编号	Q9Y275-1
别名	CD257, BAFF, TNFSF20, ZTNF4, BLYS, THANK, TALL-1, TALL1, tumor necrosis factor (ligand) superfamily, member 13b, DTL
蛋白构建	The soluble form of Human BAFF (Q9Y275-1) (Ala 134-Leu 285) was expressed and purified.
蛋白纯度	> 88 % as determined by SDS-PAGE
分子量	17.2 kDa (predicted)

内毒素	Please contact us for more information.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	B lymphocyte stimulator (BLyS), also known as TNFSF13B, CD257 and BAFF, is a single-pass type II membrane protein, which belongs to the tumor necrosis factor family. BAFF is abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), TNFRSF17 (BCMA), and TNFRSF13C (BAFFR). These receptors are a prominent factor in B cell differentiation, homeostasis, and selection. BLyS levels affect survival signals and selective apoptosis of autoantibody-producing B cells. Thus, it acts as a potent B cell activator and has been shown to play an important role in the proliferation and differentiation of B cells. Overexpression of BLyS in mice can lead to clinical and serological features of systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). BLyS is an attractive therapeutic target in human rheumatic diseases. The ability of BLyS to regulate both the size and repertoire of the peripheral B cell compartment raises the possibility that BLyS and antagonists thereof may form the basis of a therapeutic trichotomy. As an agonist, BLyS protein may enhance humoral immunity in congenital or acquired immunodeficiencies such as those resulting from viral infection or cancer therapy.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Nardelli B,et al.(2002) B lymphocyte stimulator (BLyS): a therapeutic trichotomy for the treatment of B lymphocyte diseases. Leuk Lymphoma. 43(7): 1367-73. 2. Stohl W. (2006) Therapeutic targeting of B lymphocyte stimulator (BLyS) in the rheumatic diseases. Endocr Metab Immune Disord Drug Targets. 6(4): 51-8. 3. Cancro MP,et al.(2009) The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus. J Clin Invest. 119(5): 1066-73.

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Keywords

BAFF/TNFSF13B Protein, Human, Recombinant CD257 BAFF TNFSF20 ZTNF4 CD-257 BLYS TALL 1 TNFSF-20 ZTNF 4 THANK TALL-1 CD 257 ZTNF-4 TNFSF 20 TALL1 tumor necrosis factor (ligand) superfamily, member 13b DTL recombinant recombinant-proteins proteins protein

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