Name: Letolizumab
Brand: TargetMol
SKU: T77061
Price: 2150 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 2,150

现货

5 mg

¥ 5,160

现货

10 mg

¥ 6,950

现货

25 mg

¥ 10,500

现货

50 mg

¥ 14,200

现货

生物活性

产品描述	Letolizumab (BMS-986004) is a dimeric antibody targeting CD40L for the expression of mutant IgG1 that lacks effector functions including Fc binding and complement binding.1 Letolizumab does not induce platelet activation in vitro and does not affect coagulation factors or platelet counts/function after repeated dosing in non-human primates.
靶点活性	CHO-CD40L (human):1.3 nM, CHO-CD40L (non-human primate):7.3 nM, CD40L trimer (non-human primate):3.8 nM, CD40L trimer (human):3.6 nM
体外活性	Letolizumab 抑制CD40L三聚体和CHO-CD40L在人的B细胞中和非人类灵长类的B细胞中的活力，IC50值分别为3.6 nM和1.3 nM，以及3.8 nM和7.3 nM。[2]
体内活性	2、10和20 mg/kg的剂量进行静脉注射，每周一次，持续10周的Letolizumab治疗显著延长了肾移植后恒河猴的生存时间。[2]
别名	来利珠单抗, BMS-986004, BMS986004, BMS2h-572-633-CT-L2
反应种属	Human
应用	ELISA FCM Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型	IgG1-AST-4xS

偶联与修饰

偶联	Unconjugated

抗原信息

化学信息

分子量	38.99 kDa
CAS No.	1450981-87-9

储存&溶解度

存储	Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

Letolizumab