APRIL/TNFSF13 Trimer Protein, Mouse, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is Q9D777.

Mouse

HEK293 Cells

Trdl1,Tnlg7b,Tnfsf13,Tall2,April,2310026N09Rik

A DNA sequence encoding the Mouse TNFSF13 (Q9D777) (Lys104-Leu241) was fused with the Fc region of human IgG1 at the N-terminus. This construct has a trimer design.

≥ 95% as determined by SDS-PAGE. ≥ 90% as determined by SEC-MALS(Routinely tested).

Please refer to the lot-specific COA.

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

TNFSF13 is a member of the tumor necrosis factor (TNF) ligand family. It is a ligand for TNFRSF17/BCMA. TNFSF13 is lowly expressed in normal tissues, but is elevated in several types of tumors and transformed cell lines. It is important for B cell development. TNFSF13 may also play a role in T-independent type II antigen responses and T cell survival, and induce proliferation/survival of non lymphoid cells. It exists as a functional homotrimer. It can bind to two cell surface receptors, BCMA and TACI, which it shares with BAFF to exert downstream T- and B-cell regulatory effects. TNFSF13 also has been demonstrated to bind to proteoglycans on the cell surface.