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TRAIL/TNFSF10 Protein, Mouse, Recombinant (aa 118-291, His)

产品编号 TMPY-02784

别名: A330042I21Rik, tumor necrosis factor (ligand) superfamily, member 10, APO-2L, Trail, Ly81, AI448571, TL2

TRAIL/TNFSF10 Protein, Mouse, Recombinant (aa 118-291, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22.2 kDa and the accession number is P50592.

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TRAIL/TNFSF10 Protein, Mouse, Recombinant (aa 118-291, His)

规格	价格/CNY		货期	数量
100 μg	￥ 3,430		5日内发货

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生物活性	Testing in progress
产品描述	TRAIL/TNFSF10 Protein, Mouse, Recombinant (aa 118-291, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22.2 kDa and the accession number is P50592.

种属	Mouse
表达系统	E. coli
标签	N-His
蛋白编号	P50592
别名	A330042I21Rik, tumor necrosis factor (ligand) superfamily, member 10, APO-2L, Trail, Ly81, AI448571, TL2
蛋白构建	The Mouse TNFSF10 (P50592) (Pro 118-Asn 291) was expressed, with a polyhistide tag at the N-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	22.2 kDa (predicted)

内毒素	Please contact us for more information.
缓冲液	Supplied as sterile PBS, 25% glycerol, pH7.4.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store the product under sterile conditions at -20℃ to -80℃. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Tumor necrosis factor ligand superfamily member 10 (TNFSF10), also known as TNF-related apoptosis-inducing ligand (TRAIL), Apo-2 ligand, and CD253, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TNFSF10 / Apo-2L / CD253 functions as a ligand that induces the process of cell death called apoptosis. TNFSF10 / TRAIL shows homology to other members of the tumor necrosis factor superfamily. As one member of the cluster of differentiation system, TNFSF10 / CD253 is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion TNFSF10 / Apo-2L / CD253 / TRAIL binds to several members of TNF receptor superfamily including TNFRSF10A / TRAILR1, TNFRSF10B / TRAILR2, TNFRSF10C / TRAILR3, TNFRSF10D / TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of TNFSF10 / TRAIL may be modulated by binding to the decoy receptors TNFRSF10C / TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8 / JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Song C,et al.(2005) TRAIL (CD253), a new member of the TNF superfamily. J Biol Regul Homeost Agents. 19(1-2): 73-7. 2. Kuribayashi K,et al.(2008) TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death. Cancer Biol Ther. 7(12): 2034-8. 3. Wiley SR,et al.(1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity. 3(6): 673-82.

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Keywords

TRAIL/TNFSF10 Protein, Mouse, Recombinant (aa 118-291, His) TL-2 AI-448571 A330042I21Rik tumor necrosis factor (ligand) superfamily, member 10 APO-2L Trail TL 2 Ly81 AI448571 AI 448571 TL2 recombinant recombinant-proteins proteins protein

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