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TL1A/TNFSF15 Protein, Mouse, Recombinant (hFc)

产品编号 TMPK-01013

别名: VEGI192A, TL1, VEGI-251, TL1A, TNFSF15, VEGI

TNFSF15 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 48.8 kDa and the accession number is Q5UBV8.

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TL1A/TNFSF15 Protein, Mouse, Recombinant (hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 3,100		5日内发货
500 μg	￥ 12,400		5日内发货
1 mg	￥ 20,700		5日内发货

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生物活性

技术参数

产品性质

参考文献

生物活性	1. Immobilized Mouse DR3, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Mouse TNFSF15, hFc Tag with the EC50 of 3.1ng/ml determined by ELISA. 2. Mouse TNFSF15, hFc Tag captured on CM5 Chip via Protein A can bind Mouse DR3, His Tag with an affinity constant of 4.56 nM as determined in SPR assay.
产品描述	TNFSF15 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 48.8 kDa and the accession number is Q5UBV8.

种属	Mouse
表达系统	HEK293 Cells
标签	N-hFc
蛋白编号	Q5UBV8
别名	VEGI192A, TL1, VEGI-251, TL1A, TNFSF15, VEGI
蛋白构建	Ala61-Leu252
蛋白纯度	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
分子量	48.8 kDa (predicted). Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result.

内毒素	< 1 EU/μg by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	TL1A and its functional receptor DR3 are members of the TNF/TNFR superfamilies of proteins.TL1A and DR3 are abundantly localized at inflamed intestinal areas of patients with IBD and mice with experimental ileitis or colitis and actively participate in the immunological pathways that underlie mucosal homeostasis and intestinal inflammation.Recently, an important role was demonstrated for TL1A/DR3 as potential mediators of intestinal fibrosis that is associated with the presence of gut inflammation.

参考文献

1. Valatas V, et al. TL1A (TNFSF15) and DR3 (TNFRSF25): A Co-stimulatory System of Cytokines With Diverse Functions in Gut Mucosal Immunity. Front Immunol. 2019 Mar 27;10:583. doi: 10.3389/fimmu.2019.00583. PMID: 30972074; PMCID: PMC6445966.

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Keywords

TL1A/TNFSF15 Protein, Mouse, Recombinant (hFc) VEGI 251 TNFSF 15 VEGI192A TL1 VEGI-251 TL1A TL-1 TNFSF15 TNFSF-15 VEGI251 VEGI TL 1 recombinant recombinant-proteins proteins protein

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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