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CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (hFc)

产品编号 TMPY-07034

CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is P32970-1.

CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (hFc)

CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (hFc)

产品编号 TMPY-07034
CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is P32970-1.
规格价格库存数量
100 μg
¥ 2,930
期货
1 mg 待询 期货
大包装 & 定制
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产品信息

生物活性
Immobilized CD27 Protein, Human, Recombinant (His) (Cat#TMPY-03401) at 2 μg/mL (100 μL/well) can bind CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (hFc) (Cat#TMPY-07034), the EC50 is 2-6 ng/mL.
产品描述
CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is P32970-1.
种属
Human
表达系统
HEK293 Cells
标签N-hFc
蛋白编号P32970-1
别名
TNLG8A,TNFSF7,LPFS3,CD27LG,CD27-L,CD27L
蛋白构建
A DNA sequence encoding the Human CD70(NP_001243.1) (Gln39-Pro193) was expressed with the Fc region of human IgG1 at the N-terminus. This construct has a trimer design.
蛋白纯度
≥ 90% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC.
分子量79.83 kDa (predicted); 140.1 kDa (non-reducing contition)
内毒素< 1.0 EU per μg protein as determined by the LAL method.
缓冲液Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
复溶方法
Please refer to the lot-specific COA.
存储
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式In general, Lyophilized powders are shipping with blue ice.
研究背景
CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor, CD27, is important in priming, effector functions, differentiation and memory formation of T-cells as well as plasma and memory B-cell generation. Tight control of CD70 expression is required to prevent lethal immunodeficiency. By selective transcription, CD70 is largely confined to activated lymphocytes and dendritic cells (DC). As a type II transmembrane receptor, CD70 is normally expressed on a subset of B, T and NK cells, where it plays a costimulatory role in immune cell activation. Immunohistochemical analysis of CD70 expression in multiple carcinoma types. The restricted expression pattern of CD70 in normal tissues and its widespread expression in various malignancies makes it an attractive target for antibody-based therapeutics. Investigations to exploit CD70 as a cancer target have lead to the identification of potential antibody-based clinical candidates.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy

参考文献

SCI 文献

计算器

  • 复溶 计算器
  • 重组蛋白稀释 计算器
  • 比活力 计算器

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