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Anti-DR5/TRAIL R2 Antibody (9F7)
还可以产品编号 TMAY-00863
Anti-DR5/TRAIL R2 Antibody (9F7) 是一种 Mouse 抗体，靶向 DR5/TRAIL R2。Anti-DR5/TRAIL R2 Antibody (9F7) 可用于 ELISA,ICC/IF。
Anti-DR5/TRAIL R2 Antibody (9F7)
Anti-DR5/TRAIL R2 Antibody (9F7)
还可以产品编号 TMAY-00863
Anti-DR5/TRAIL R2 Antibody (9F7) 是一种 Mouse 抗体，靶向 DR5/TRAIL R2。Anti-DR5/TRAIL R2 Antibody (9F7) 可用于 ELISA,ICC/IF。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-DR5/TRAIL R2 Antibody (9F7) is a Mouse antibody targeting DR5/TRAIL R2. Anti-DR5/TRAIL R2 Antibody (9F7) can be used in ELISA,ICC/IF. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 9F7 |
| 交叉反应 | Human |
| 验证活性 | Immunofluorescence staining of TNFRSF10B in HCT116 cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS,blocked with 10% serum, and incubated with mouse anti-Human TNFRSF10B monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-mouse IgG secondary antibody (green) and counterstained with DAPI (blue).Positive staining was localized to Cytoplasm. |
| 应用 | ELISA,ICC/IF |
| 推荐剂量 | ELISA: 1:1000-1:2000; ICC-IF: 1:20-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This product is a recombinant monoclonal antibody expressed from HEK293 cells. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, also known as Death receptor 5, CD262, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL R2), is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R2/CD262/TNFRSF10B was purified independently as the only receptor for TRAIL detectable on the surface of two different human cell lines that undergo apoptosis upon stimulation with TRAIL. TRAIL R2/CD262/TNFRSF10B contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain. TRAIL R2/CD262/TNFRSF10B mediates apoptosis via the intracellular adaptor molecule FADD/MORT1. TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family. Defects in TRAIL R2/CD262/TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) also known as squamous cell carcinoma of the head and neck.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human DR5/TRAIL R2 Protein (TMPY-01185) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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