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顶部产品介绍偶联与修饰抗原信息储存和溶解信息计算器

Anti-DR5/TRAIL R2 Antibody (9F7)

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货号 TMAY-00863

别名 ZTNFR9, tumor necrosis factor receptor superfamily, member 10b, TRICKB, TRICK2B, TRICK2A, TRICK2, TRAIL-R2, TRAILR2, KILLER/DR5, KILLER, DR5, CD262

Anti-DR5/TRAIL R2 Antibody (9F7) 是一种 Mouse 抗体，靶向 DR5/TRAIL R2。Anti-DR5/TRAIL R2 Antibody (9F7) 可用于 ELISA,ICC/IF。

Anti-DR5/TRAIL R2 Antibody (9F7)

Anti-DR5/TRAIL R2 Antibody (9F7)

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货号 TMAY-00863 别名 ZTNFR9, tumor necrosis factor receptor superfamily, member 10b, TRICKB, TRICK2B, TRICK2A, TRICK2, TRAIL-R2, TRAILR2, KILLER/DR5, KILLER, DR5, CD262

Anti-DR5/TRAIL R2 Antibody (9F7) 是一种 Mouse 抗体，靶向 DR5/TRAIL R2。Anti-DR5/TRAIL R2 Antibody (9F7) 可用于 ELISA,ICC/IF。

规格价格库存数量
100 μL
¥ 1,694
5日内发货
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产品介绍

生物活性
产品描述
Anti-DR5/TRAIL R2 Antibody (9F7) is a Mouse antibody targeting DR5/TRAIL R2. Anti-DR5/TRAIL R2 Antibody (9F7) can be used in ELISA,ICC/IF.
别名ZTNFR9, tumor necrosis factor receptor superfamily, member 10b, TRICKB, TRICK2B, TRICK2A, TRICK2, TRAIL-R2, TRAILR2, KILLER/DR5, KILLER, DR5, CD262
Ig Type
Mouse IgG1
克隆号
9F7
反应种属
Human
特异性
Human DR5/TRAIL R2
验证活性
Immunofluorescence staining of TNFRSF10B in HCT116  cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS,blocked with 10% serum, and incubated with mouse anti-Human TNFRSF10B monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-mouse IgG secondary antibody (green) and counterstained with DAPI (blue).Positive staining was localized to Cytoplasm.
应用ELISAICC/IF
推荐剂量
ELISA: 1:1000-1:2000; ICC-IF: 1:20-1:100
抗体种类
Monoclonal
宿主来源Mouse
构建方式This product is a recombinant monoclonal antibody expressed from HEK293 cells.
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, also known as Death receptor 5, CD262, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL R2), is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R2/CD262/TNFRSF10B was purified independently as the only receptor for TRAIL detectable on the surface of two different human cell lines that undergo apoptosis upon stimulation with TRAIL. TRAIL R2/CD262/TNFRSF10B contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain. TRAIL R2/CD262/TNFRSF10B mediates apoptosis via the intracellular adaptor molecule FADD/MORT1. TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family. Defects in TRAIL R2/CD262/TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) also known as squamous cell carcinoma of the head and neck.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human DR5/TRAIL R2 Protein (TMPY-01185)
抗原种属
Human
研究领域
Cancer Drug Targets
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.
存储-20°C for 1 year

计算器

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关键词

ZTNFR-9ZTNFR 9TRICK-2TRICK 2TRAILR-2TRAILR 2DR-5DR 5CD-262CD 262
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