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Anti-TNFR2/CD120b/TNFR1B Antibody (4D489)
还可以产品编号 TMAY-03889
Anti-TNFR2/CD120b/TNFR1B Antibody (4D489) 是一种 Mouse 抗体，靶向 TNFR2/CD120b/TNFR1B。Anti-TNFR2/CD120b/TNFR1B Antibody (4D489) 可用于 ELISA。
Anti-TNFR2/CD120b/TNFR1B Antibody (4D489)
Anti-TNFR2/CD120b/TNFR1B Antibody (4D489)
还可以产品编号 TMAY-03889
Anti-TNFR2/CD120b/TNFR1B Antibody (4D489) 是一种 Mouse 抗体，靶向 TNFR2/CD120b/TNFR1B。Anti-TNFR2/CD120b/TNFR1B Antibody (4D489) 可用于 ELISA。
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抗原信息
| 产品描述 | Anti-TNFR2/CD120b/TNFR1B Antibody (4D489) is a Mouse antibody targeting TNFR2/CD120b/TNFR1B. Anti-TNFR2/CD120b/TNFR1B Antibody (4D489) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 4D489 |
| 交叉反应 | Cynomolgus, Rhesus |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Cynomolgus / Rhesus TNFR2 / CD120b / TNFRSF1B (XP_005544817.1/NP_001253134.1; Met1-Asp257). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD120b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD120b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Cynomolgus / Rhesus TNFR2 / CD120b / TNFRSF1B Protein (TMPY-03101) |
| 抗原种属 | Cynomolgus, Rhesus |
| 研究领域 | Neuroinflammation |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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