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Anti-LIGHT/TNFSF14 Polyclonal Antibody
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产品编号 TMAB-01068
Anti-LIGHT/TNFSF14 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 LIGHT/TNFSF14。Anti-LIGHT/TNFSF14 Polyclonal Antibody 可用于 WB,ELISA。
Anti-LIGHT/TNFSF14 Polyclonal Antibody
Anti-LIGHT/TNFSF14 Polyclonal Antibody
还可以产品编号 TMAB-01068
Anti-LIGHT/TNFSF14 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 LIGHT/TNFSF14。Anti-LIGHT/TNFSF14 Polyclonal Antibody 可用于 WB,ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,165 | 5日内发货 | |
| 100 μL | ¥ 1,965 | 5日内发货 | |
| 200 μL | ¥ 2,790 | 5日内发货 |
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产品介绍
生物活性
抗原信息
| 产品描述 | Anti-LIGHT/TNFSF14 Polyclonal Antibody is a Rabbit antibody targeting LIGHT/TNFSF14. Anti-LIGHT/TNFSF14 Polyclonal Antibody can be used in WB,ELISA. |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse (predicted:Rat) |
| 验证活性 | Sample: Spleen (Mouse) Lysate at 40 μg Small intestine (Mouse) Lysate at 40 μg Primary: Anti-TNFSF14 (TMAB-01068) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 26 kDa Observed band size: 26 kDa |
| 应用 | |
| 推荐剂量 | WB: 1:500-2000; ELISA: 1:500-5000 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Tumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass type II membrane protein.Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted.Isoform 2: Cytoplasm. |
| 构建方式 | Hybridoma Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究背景 | LIGHT protein is a type II transmembrane protein and a tumor necrosis factor (TNF) ligand superfamily member (TNFSF14). LIGHT is expressed on activated T cells and immature dendritic cells and its receptors have been identified as lymphotoxin-Beta receptor (LTBetaR) and the herpesvirus entry mediator (HVEM), both of which lack the cytoplasmic sequence termed as "death domain." LIGHT is first identified as HVEM ligand (HVEM-L) and a deterrent to herpesvirus infection according to its ability to compete with HSV glycoprotein D for HVEM binding. As a T cell-derived costimulatory ligand, TNFSF14 plays a crucial role in T cell activation and proliferation by LIGHT-LTBetaR interaction, and it is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. Additionally, recent studies also establish a direct role for LIGHT in NK activation/expansion via LIGHT-HVEM interaction, and thus breaking T-cell tolerance at the tumor site. Accordingly, LIGHT is suggested to be involved in CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Although known as lymphotoxin-Gamma, LIGHT plays a minimal role in lymphoid tissue development in contrast with LT-Alpha and Beta. This protein was also demonstrated to inhibit TNF-Alpha-mediated but not Fas- or TRAIL-mediated apoptosis of human primary hepatocytes. |
| 免疫原 | KLH conjugated synthetic peptide: human TNFSF14 |
| 抗原种属 | Human |
| 基因ID | |
| Uniprot ID |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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