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4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (hFc)

产品编号 TMPY-06831

别名: 4-1BB-L, Ly63l, 4-1BBL, Cd137l, tumor necrosis factor (ligand) superfamily, member 9, AI848817

4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.41 kDa and the accession number is NP_033430.1.

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 4,460		5日内发货
1 mg	￥ 29,000		5日内发货

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参考文献

生物活性	Immobilized Recombinant Mouse TNFRSF9 / CD137 / 4-1BB Protein (soluble form, His Tag) at 2μg/mL (100μL/well) can bind Recombinant Mouse 4-1BB Ligand/TNFSF9 Protein (Fc Tag) , the EC50 is 2-6 ng/mL.
产品描述	4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.41 kDa and the accession number is NP_033430.1.

种属	Mouse
表达系统	HEK293 Cells
标签	N-hFc
蛋白编号	NP_033430.1
别名	4-1BB-L, Ly63l, 4-1BBL, Cd137l, tumor necrosis factor (ligand) superfamily, member 9, AI848817
蛋白构建	The Mouse TNFSF9 (NP_033430.1) (Arg104-Glu309) was expressed with the Fc region of Human IgG1 at the N-terminus.
蛋白纯度	≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
分子量	51.41 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as dendritic cells, macrophages, and activated B cells. Members of the TNF-TNF receptor superfamily have been shown to play critical roles in regulating cellular activation, differentiation and apoptosis. Several studies have reported that 4-1BBL/4-1BB interaction provided a co-stimulatory signal to T cells, and increased T cell proliferation and cytokines production. In addition, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: ICC AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy

参考文献

1. Cheung CT, (2007) Neutralizing anti-4-1BBL treatment improves cardiac function in viral myocarditis. Lab Invest. 87(7): 651-61. 2. Wang C, et al. (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol Rev. 229(1): 192-215. 3. HAbib-Agahi M, et al. (2009) 4-1BBL costimulation retrieves CD28 expression in activated T cells. Cell Immunol. 256(1-2): 39-46.

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Keywords

4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (hFc) 4-1BB-L Ly63l 4-1BBL AI 848817 Cd137l tumor necrosis factor (ligand) superfamily, member 9 AI848817 AI-848817 recombinant recombinant-proteins proteins protein

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