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TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (hFc)

TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (hFc)

产品编号 TMPJ-00246
别名: MK, CD262, Tnfrsf10b, Dr5, Tumor necrosis factor receptor superfamily member 10B, Killer, Death receptor 5

TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 50-75 KDa and the accession number is Q9QZM4.

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TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (hFc)
规格 价格/CNY 货期 数量
10 μg ¥ 740 5日内发货
50 μg ¥ 1,970 5日内发货
500 μg ¥ 12,100 5日内发货
1 mg ¥ 17,400 5日内发货
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产品目录号及名称: TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (hFc) (TMPJ-00246)
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产品描述 TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 50-75 KDa and the accession number is Q9QZM4.
种属 Mouse
表达系统 HEK293 Cells
标签 C-hFc
蛋白编号 Q9QZM4
别名 MK, CD262, Tnfrsf10b, Dr5, Tumor necrosis factor receptor superfamily member 10B, Killer, Death receptor 5
氨基酸序列 Asn53-Ser177
蛋白构建 Asn53-Ser177
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 50-75 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Mouse tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is a member of the TNFR family which contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10B exhibits high structural and functional homology to TRAIL-R1 (DR-4). TNFRSF10B is highly expressed in heart, lung, lymphocytes, spleen and kidney. In addition, it is regulated by the tumor suppressor p53. TNFRSF10B is the receptor for the cytotoxic ligand TNFSF10/TRAIL. It promotes the activation of NF-kappa-B and is essential for ER stress-induced apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis.

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Keywords

TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (hFc) MK CD262 Tnfrsf10b Dr5 CD-262 Tumor necrosis factor receptor superfamily member 10B Killer Death receptor 5 CD 262 recombinant recombinant-proteins proteins protein

 

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