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BAFF/TNFSF13B Protein, Human, Recombinant (His)

BAFF/TNFSF13B Protein, Human, Recombinant (His)

产品编号 TMPJ-00178
别名: B lymphocyte stimulator, TNF- and APOL-related leukocyte expressed ligand 1, TALL-1, BLyS, BAFF, Tumor necrosis factor ligand superfamily member 13B, Dendritic cell-derived TNF-like molecule, B-cell-activating factor

BAFF/TNFSF13B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 22 KDa and the accession number is Q9Y275.

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BAFF/TNFSF13B Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
10 μg ¥ 850 5日内发货
50 μg ¥ 2,570 5日内发货
500 μg ¥ 14,200 5日内发货
1 mg ¥ 21,300 5日内发货
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产品目录号及名称: BAFF/TNFSF13B Protein, Human, Recombinant (His) (TMPJ-00178)
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生物活性
技术参数
产品性质
生物活性 1. Loaded Human BCMA-Fc on Protein A Biosensor, can bind Human BAFF-His with an affinity constant of 0.02 nM as determined in BLI assay. (Regularly tested)2 . Immobilized Human BAFF-His at 10μg/ml (100 μl/well) can bind Mouse BCMA-Fc . The ED50 of Recombinant Mouse BCMA-Fc is 0.016 ug/ml. (Regularly tested)
产品描述 BAFF/TNFSF13B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 22 KDa and the accession number is Q9Y275.
种属 Human
表达系统 HEK293 Cells
标签 N-6xHis
蛋白编号 Q9Y275
别名 B lymphocyte stimulator, TNF- and APOL-related leukocyte expressed ligand 1, TALL-1, BLyS, BAFF, Tumor necrosis factor ligand superfamily member 13B, Dendritic cell-derived TNF-like molecule, B-cell-activating factor
氨基酸序列 Ala134-Leu285
蛋白构建 Ala134-Leu285
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 22 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 TNFSF13B/TNFSF20 belongs to the tumor necrosis factor family. It abundantly is expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines. Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3 acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. Isoform 2 heteromultimerizes with isoform 1, probably limiting the amount of functional isoform 1 on the cell surface. Isoform 3 is unlikely form trimers or bind to BAFF receptors. Mature human BAFF consists of a 46 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 218 aa extracellular domain (ECD) with a stalk region and one TNF-like domain. Within aa 134-285 of the ECD, human BAFF shares 72% aa sequence identity with mouse BAFF.

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Keywords

BAFF/TNFSF13B Protein, Human, Recombinant (His) B lymphocyte stimulator TNF- and APOL-related leukocyte expressed ligand 1 TALL-1 TALL 1 BLyS BAFF Tumor necrosis factor ligand superfamily member 13B TALL1 Dendritic cell-derived TNF-like molecule B-cell-activating factor recombinant recombinant-proteins proteins protein

 

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