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Anti-4-1BB/CD137/TNFRSF9 Antibody (9J469)

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Anti-4-1BB/CD137/TNFRSF9 Antibody (9J469)
产品编号 TMAY-00149
别名 tumor necrosis factor receptor superfamily, member 9, Ly63, ILA, CDw137, Cd137, AI325004, AA408498, A930040I11Rik, 4-1BB

Anti-4-1BB/CD137/TNFRSF9 Antibody (9J469) 是一种 Rabbit 抗体,靶向 4-1BB/CD137/TNFRSF9。Anti-4-1BB/CD137/TNFRSF9 Antibody (9J469) 可用于 FCM。

Anti-4-1BB/CD137/TNFRSF9 Antibody (9J469)

Anti-4-1BB/CD137/TNFRSF9 Antibody (9J469)

Rating icon 还可以
Anti-4-1BB/CD137/TNFRSF9 Antibody (9J469)
产品编号 TMAY-00149 别名 tumor necrosis factor receptor superfamily, member 9, Ly63, ILA, CDw137, Cd137, AI325004, AA408498, A930040I11Rik, 4-1BB

Anti-4-1BB/CD137/TNFRSF9 Antibody (9J469) 是一种 Rabbit 抗体,靶向 4-1BB/CD137/TNFRSF9。Anti-4-1BB/CD137/TNFRSF9 Antibody (9J469) 可用于 FCM。

规格价格库存数量
100 μL
¥ 2,294
5日内发货
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TargetMol 的所有产品仅用作科学研究或药证申报,不能被用于人体,我们不向个人提供产品和服务。请您遵守承诺用途,不得违反法律法规规定用于任何其他用途。
实验操作小课堂
常见问题解答
化合物带有盐酸盐离子、硫酸盐离子等是否和其本身有什么区别?盐形式和游离态有什么区别?
盐和非盐形式化合物的活性分子是一样的,在生物实验中起到的效果也一致,活性和使用方法都是一样的。只是由于呈盐不同,物理性质比如溶解度会有差异。建议您根据溶解、实验需求进行选择。
如何选择某个靶点的特异性或总的抑制剂?特异性和非特异性的区别是什么?
抑制剂按照特异性分为广谱 pan 和特异性 selective 两种。Pan 为某个靶点总的抑制剂,对所有亚型或整个家族的成员都有抑制作用。Selective 抑制剂针对某个蛋白激酶的某个亚型或家族中某个成员抑制率特别高或有特异性抑制作用。 一般评价一个抑制剂的抑制效率主要看 IC50 值,IC50 值越低,说明抑制剂效率越高。建议您根据以上几个特征进行综合选择,也可联系技术帮您推荐相关抑制剂。
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产品介绍

生物活性
产品描述
Anti-4-1BB/CD137/TNFRSF9 Antibody (9J469) is a Rabbit antibody targeting 4-1BB/CD137/TNFRSF9. Anti-4-1BB/CD137/TNFRSF9 Antibody (9J469) can be used in FCM.
别名tumor necrosis factor receptor superfamily, member 9, Ly63, ILA, CDw137, Cd137, AI325004, AA408498, A930040I11Rik, 4-1BB
Ig Type
Rabbit IgG
克隆号
9J469
交叉反应
Human
验证活性
Flow cytometric analysis of Human CD137 expression on PHA-activated human whole blood lymphocytes. Cells were stained with purified anti-Human CD137, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.
应用
推荐剂量
FCM: 1:25-1:100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human CD137 (rh CD137; TMPY-01743; NP_001552.2; Met1-Gln186).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+and CD8+T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor necrosis factor receptor–associated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses. In addition, CD137 and CD137L are expressed in different human primary tumor tissues, suggesting that they may influence the progression of tumors. Crosslinking of CD137 on activated T cells has shown promise in enhancing anti-tumor immune responses in murine models, and agonistic anti-CD137 antibodies are currently being tested in phase I clinical trials. Soluble forms of CD137 (sCD137) are generated by differential splicing. sCD137 can bind to CD137 ligand to antagonize the costimulatory activities of the membrane-bound CD137 and reduce T cell proliferation and IL-2 secretion.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy
偶联与修饰
偶联
Unconjugated
其他可选修饰符
FITC/PE
可提供抗体种类
3
抗原信息
免疫原
Recombinant Protein: Human CD137 Protein (TMPY-01743)
抗原种属
Human
研究领域
Cancer Drug Targets
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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